Pain intensity VAS (0 to 100; 0 = no pain, 100 = worst pain) · people with acute soft tissue injury, such as ankle sprain
1 finding from 1 review
Little or no swelling on day 7 or later · people with acute soft tissue injury, such as ankle sprain
NSAID showed no clear difference in little or no swelling on day 7 or later compared with paracetamol (low certainty).
1 finding from 1 review
Return to function on day 7 or later (numbers returning to full function or returning to training) · people with acute soft tissue injury, such as ankle sprain
It is very uncertain whether NSAID changes return to function on day 7 or latere compared with paracetamol (very low certainty).
1 finding from 1 review
Gastrointestinal adverse events · people with acute soft tissue injury, such as ankle sprain
NSAID showed no clear difference in gastrointestinal adverse events compared with paracetamol (low certainty).
1 finding from 1 review
Neurological adverse effects · people with acute soft tissue injury, such as ankle sprain
NSAID showed no clear difference in neurological adverse events compared with paracetamol (low certainty).
1 finding from 1 review
Early re‐injury (with 3 months) · people with acute soft tissue injury, such as ankle sprain
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Incidence of mortality · first aid in patients with acute oral poisoning (paracetamol or not specified)
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Incidence of adverse events · first aid in patients with acute oral poisoning (paracetamol or not specified)
1 finding from 1 review
Incidence and severity of symptoms of poisoning: incidence of clinical deterioration during stay in the hospital · first aid in patients with acute oral poisoning (paracetamol or not specified)
1 finding from 1 review
Duration of toxic symptoms · first aid in patients with acute oral poisoning (paracetamol or not specified)
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Drug absorption · first aid in patients with acute oral poisoning (paracetamol or not specified)
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Hospitalization · first aid in patients with acute oral poisoning (paracetamol or not specified)
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Incidence of admissions to the ICU · first aid in patients with acute oral poisoning (paracetamol or not specified)
1 finding from 1 review
Rescue analgesia · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)
It is very uncertain whether NSAID (systemic) changes rescue analgesia compared with paracetamol (very low certainty).
1 finding from 1 review
Adverse events · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)
1 finding from 1 review
In one study, one participant (<1%) in the paracetamol group experienced drug hypersensitivity (a 'red, blotchy and itchy rash') that resolved without treatment within 1 week (Bradley 2007 / McAlinden 2005); 1 RCT;…
1 study
Very low
Time off school or work · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)
The review found no eligible studies for this question.
1 finding from 1 review
Quality of life or participant satisfaction · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)
The review found no eligible studies for this question.
1 finding from 1 review
Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)
NSAID (systemic) showed no clear difference in pain intensity (VAS 0-100 mm) compared with paracetamol (low certainty).
3 findings from 1 review
MD -5.17 [-11.71, 1.37]
7 studies · 664 participants
Low
MD -0.51 [-8.93, 7.92]
9 studies · 734 participants
Low
MD -2.92 [-8.48, 2.65]
7 studies · 664 participants
Low
Failure to complete orthodontic treatment due to pain · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)
The review found no eligible studies for this question.
1 finding from 1 review
Relief of pain · women with primary dysmenorrhoea
NSAIDs may leads to higher pain relief dichotomous data compared with paracetamol (low certainty).
1 finding from 1 review
OR 1.89 [1.05, 3.43]
Studies not reported
Low