Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

372 questions · 521 findings · 37 reviews

No studies found 9 · 1.7%GRADE not reported 477 · 91.6%Very low 11 · 2.1%Low 16 · 3.1%Moderate 7 · 1.3%High 1 · 0.2%

Dental caries assessment (WHO/clinical diagnostic criteria; caries = DMFT>0) vs None (descriptive prevalence meta-analysis)

Dental caries prevalence · General Pakistani population (all ages and both sexes; predominantly children and adolescents)

In permanent dentition, the pooled prevalence of dental caries was 57.2% (95% CI 26.3 to 85.3); ungraded.

10 findings from 1 review
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Not applicable (single-group prevalence) vs Not applicable

Dental caries prevalence · General Pakistani population (all ages and both sexes; predominantly children and adolescents)

Fixed-effect pooled dental caries prevalence was 57.0% (95% CI 56.4% to 57.6%).

1 finding from 1 review

Systemic sclerosis (SSc / scleroderma) vs SSc-free individuals (controls)

Periodontitis (prevalence) · Adults (general and hospital populations assessed in case-control studies)

Periodontitis prevalence is significantly higher in systemic sclerosis patients than controls (OR 7.01); certainty ungraded.

1 finding from 1 review

Intervention not reported

Dental caries prevalence · General population in Ethiopia (all ages, age range 6-100 years)

Caries prevalence was lowest in Addis Ababa at 34.20% (95% CI 8.42 to 59.97); certainty not graded.

1 finding from 1 review

Intervention not reported

Dental caries prevalence · General population in Ethiopia (all ages, age range 6-100 years)

Caries prevalence in the Amhara region was 40.44% (95% CI 24.67 to 56.21); certainty not graded.

1 finding from 1 review

Systemic sclerosis (SSc / scleroderma) vs SSc-free individuals (controls)

Mean number of decayed teeth (mean DT) · Adults (general and hospital populations assessed in case-control studies)

Systemic sclerosis patients have a significantly higher number of decayed teeth than controls (SMD 0.19); certainty ungraded.

1 finding from 1 review

Intervention not reported

Dental caries prevalence · General population in Ethiopia (all ages, age range 6-100 years)

Caries prevalence in other regions (Oromia, Harar, SNNPR) was 42.90% (95% CI 24.68 to 61.12); certainty not graded.

1 finding from 1 review

Intervention not reported

Dental caries prevalence · General population in Ethiopia (all ages, age range 6-100 years)

Caries prevalence was highest in the Tigray region at 46.59% (95% CI 24.64 to 68.54); certainty not graded.

1 finding from 1 review

Intervention not reported

Dental caries prevalence · General population in Ethiopia (all ages, age range 6-100 years)

The pooled prevalence of dental caries in Ethiopia (2000-2020) was 40.98% (95% CI 31.62 to 50.34), with very high heterogeneity (I2=98.6%); certainty not graded.

1 finding from 1 review

Gum chewing (sugar-free) vs Pooled controls: no gum, placebo/control gum, probiotic, or fluoride varnish

Streptococcus mutans load in the oral cavity (saliva and/or dental plaque) · Adults and children (general population)

In a sensitivity analysis assuming a 0.95 baseline-to-endpoint correlation for the sugar-free gum arm, the effect remained significant (SMD -0.55, 95% CI -0.80 to -0.30; 13 trials, I2 73%); certainty not formally graded.

2 findings from 1 review

Systemic sclerosis (SSc / scleroderma) vs SSc-free individuals (controls)

DMFT/DMFS index (dental caries experience) · Adults (general and hospital populations assessed in case-control studies)

No statistically significant difference in DMFT index between SSc patients and controls (SMD -0.03, CI includes 0); certainty ungraded.

1 finding from 1 review

Systemic sclerosis (SSc / scleroderma) vs SSc-free individuals (controls)

Maximal mouth opening (interincisal distance) · Adults (general and hospital populations assessed in case-control studies)

Systemic sclerosis patients have significantly reduced mouth opening compared with controls (SMD -1.06); certainty ungraded.

1 finding from 1 review

Systemic sclerosis (SSc / scleroderma) vs SSc-free individuals (controls)

Number of teeth · Adults (general and hospital populations assessed in case-control studies)

No statistically significant difference in number of teeth between SSc patients and controls (SMD -0.95, CI includes 0); certainty ungraded.

1 finding from 1 review

Intervention not reported

Dental caries prevalence · General population (children and adults) in East Africa

Caries prevalence in mixed dentition (6-12 years) was 41.3% (95% CI 33.5 to 49.2); certainty not graded.

1 finding from 1 review

Systemic sclerosis (SSc / scleroderma) vs SSc-free individuals (controls)

Mean number of missing teeth in OC cases vs controls · Adults (general and hospital populations assessed in case-control studies)

No statistically significant difference in number of missing teeth between SSc patients and controls (SMD 0.55, CI includes 0); certainty ungraded.

1 finding from 1 review

Systemic sclerosis (SSc / scleroderma) vs SSc-free individuals (controls)

Percentage of bleeding on probing (BOP) · Adults (general and hospital populations assessed in case-control studies)

No statistically significant difference in bleeding on probing between SSc patients and controls (SMD 1.05, CI includes 0); certainty ungraded.

1 finding from 1 review