Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

333 questions · 350 findings · 60 reviews

No studies found 120 · 34.3%GRADE not reported 17 · 4.9%Very low 97 · 27.7%Low 81 · 23.1%Moderate 25 · 7.1%High 10 · 2.9%

Oral clonazepam (benzodiazepine) vs placebo

Pain on palpation of right masseter muscle (VAS) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral clonazepam (benzodiazepine) showed no clear difference in pain on palpation of right masseter muscle (VAS) compared with placebo; GRADE not reported.

1 finding from 1 review

Topical methyl salicylate (Theraflex-TMJ) vs placebo

Spontaneous masseter muscle pain (numerical graph rating scale) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Topical methyl salicylate (Theraflex-TMJ) led to lower spontaneous masseter muscle pain (numerical graph rating scale) compared with placebo; GRADE not reported.

1 finding from 1 review

Oral clonazepam (benzodiazepine) vs placebo

Pain on palpation of left masseter muscle (VAS) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral clonazepam (benzodiazepine) showed no clear difference in pain on palpation of left masseter muscle (VAS) compared with placebo; GRADE not reported.

1 finding from 1 review

Ultrasound‐assisted catheter‐directed thrombolysis plus standard intravenous heparinisation vs standard intravenous heparinisation

All‐cause mortality (90‐day) · people with intermediate‐risk (submassive) APE

It is very uncertain whether ultrasound‐assisted catheter‐directed thrombolysis plus standard… changes all‐cause mortality (90‐day) compared with standard intravenous heparinisation (very low certainty).

1 finding from 1 review

Ultrasound‐assisted catheter‐directed thrombolysis plus standard intravenous heparinisation vs standard intravenous heparinisation

Treatment‐associated minor haemorrhage ( · people with intermediate‐risk (submassive) APE

It is very uncertain whether ultrasound‐assisted catheter‐directed thrombolysis plus standard… changes treatment‐associated minor haemorrhage ( compared with standard intravenous heparinisation (very low certainty).

1 finding from 1 review

Ultrasound‐assisted catheter‐directed thrombolysis plus standard intravenous heparinisation vs standard intravenous heparinisation

Recurrent APE requiring retreatment or change to a different APE treatment ( · people with intermediate‐risk (submassive) APE
1 finding from 1 review

Zinc vs placebo

BMD Z score (total hip/femoral neck) · children and adults with β‐thalassaemia major and low bone mass

Summary of findings – zinc probably leads to higher BMD Z score (total hip/femoral neck) compared with placebo (moderate certainty).

1 finding from 1 review

Zinc vs placebo

BMD Z score (lumbar spine) · children and adults with β‐thalassaemia major and low bone mass

Summary of findings – zinc probably leads to higher BMD Z score (lumbar spine) compared with placebo (moderate certainty).

1 finding from 1 review