Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

321 questions · 328 findings · 23 reviews · Skin

No studies found 119 · 36.3%GRADE not reported 15 · 4.6%Very low 64 · 19.5%Low 72 · 22%Moderate 41 · 12.5%High 17 · 5.2%

Cetirizine 10 mg/d vs placebo (4‐week intervention)

Primary outcome 2. Proportion of participants reporting adverse effects and serious adverse events throughout the study period · adults with eczema

Cetirizine 10 mg/d showed no clear difference in primary outcome 2. Proportion of participants reporting adverse… compared with placebo (4‐week intervention) (low certainty).

1 finding from 1 review

Complete cure and adverse events for terbinafine vs griseofulvin

Proportion of participants with complete cure · children with tinea capitis

Complete cure and adverse events for terbinafine showed no clear difference in proportion of participants with complete cure compared with griseofulvin (low certainty).

4 findings from 1 review
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Complete cure for ketoconazole vs griseofulvin

Proportion of participants with complete cure · children infected with Trichophyton

Complete cure for ketoconazole showed no clear difference in proportion of participants with complete cure compared with griseofulvin (low certainty).

2 findings from 1 review

Complete cure for fluconazole vs griseofulvin

Proportion of participants with complete cure · children with tinea capitis

Complete cure for fluconazole showed no clear difference in proportion of participants with complete cure compared with griseofulvin (moderate certainty).

2 findings from 1 review

Intervention not reported

Proportion of participants with complete cure · children infected with T. tonsurans and M. canis

The intervention showed no clear difference in proportion of participants with complete cure (low certainty).

1 finding from 1 review