Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

339 questions · 355 findings · 25 reviews

No studies found 134 · 37.7%GRADE not reported 38 · 10.7%Very low 87 · 24.5%Low 66 · 18.6%Moderate 27 · 7.6%High 3 · 0.8%

Risk of transient neurological symptoms with spinal lidocaine vs other local anaesthetic

Presence of any TNS – lidocaine vs levobupivacaine · adults undergoing surgery

Risk of transient neurological symptoms with spinal lidocaine may leads to lower presence of any TNS – lidocaine vs levobupivacaine compared with other local anaesthetic (low certainty).

1 finding from 1 review

Risk of transient neurological symptoms with spinal lidocaine vs other local anaesthetic

Presence of any TNS – lidocaine vs mepivacaine · adults undergoing surgery

It is very uncertain whether risk of transient neurological symptoms with spinal lidocaine changes presence of any TNS – lidocaine vs mepivacaine compared with other local anaesthetic (very low certainty).

1 finding from 1 review

Risk of transient neurological symptoms with spinal lidocaine vs other local anaesthetic

Presence of any TNS – lidocaine vs prilocaine · adults undergoing surgery

Risk of transient neurological symptoms with spinal lidocaine probably leads to lower presence of any TNS – lidocaine vs prilocaine compared with other local anaesthetic (moderate certainty).

1 finding from 1 review

Risk of transient neurological symptoms with spinal lidocaine vs other local anaesthetic

Presence of any TNS – lidocaine vs procaine · adults undergoing surgery

Risk of transient neurological symptoms with spinal lidocaine probably leads to lower presence of any TNS – lidocaine vs procaine compared with other local anaesthetic (moderate certainty).

1 finding from 1 review

Risk of transient neurological symptoms with spinal lidocaine vs other local anaesthetic

Presence of any TNS – lidocaine vs ropivacaine · adults undergoing surgery

Risk of transient neurological symptoms with spinal lidocaine may leads to lower presence of any TNS – lidocaine vs ropivacaine compared with other local anaesthetic (low certainty).

1 finding from 1 review

Topical anaesthetic gel (prilocaine-lidocaine) vs Eugenol

Pain at 48 hours (VAS 0-10) · Adults (>18 years) with established dry socket following permanent tooth extraction

Topical anaesthetic gel (prilocaine-lidocaine) showed no clear difference in pain at 48 hours (VAS 0-10) compared with eugenol; GRADE not reported.

1 finding from 1 review

2% mepivacaine, 1:20,000 levonordefrin vs 2% lidocaine, 1:100,000 epinephrine

Duration of anaesthesia (soft tissue, simulated) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

It is very uncertain whether 2% mepivacaine, 1:20,000 levonordefrin changes duration of anaesthesia (soft tissue, simulated) compared with 2% lidocaine, 1:100,000 epinephrine (very low certainty).

1 finding from 1 review

4% prilocaine plain vs 2% lidocaine, 1:100,000 epinephrine

Adverse effects: pain following injection · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

The review found no eligible studies for this question.

2 findings from 1 review

4% articaine, 1:100,000 epinephrine vs 2% mepivacaine, 1:100,000 epinephrine

Adverse effects: pain following injection · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

The review found no eligible studies for this question.

2 findings from 1 review

4% articaine, 1:200,000 epinephrine vs 4% articaine, 1:100,000 epinephrine

Adverse effects: pain following injection · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…
2 findings from 1 review

4% articaine, 1:200,000 epinephrine vs 4% articaine, 1:100,000 epinephrine

Duration of anaesthesia (pulpal, electric pulp tester; healthy pulps) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

It is very uncertain whether 4% articaine, 1:200,000 epinephrine changes duration of anaesthesia (pulpal, electric pulp tester; healthy pulps) compared with 4% articaine, 1:100,000 epinephrine (very low certainty).

1 finding from 1 review