Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

551 questions · 579 findings · 72 reviews · Headline outcomes only

No studies found 158 · 27.3%GRADE not reported 44 · 7.6%Very low 173 · 29.9%Low 112 · 19.3%Moderate 66 · 11.4%High 26 · 4.5%

Radiotherapy vs botulinum toxin

Adverse events, reported as "negative experiences" · sialorrhea (excessive saliva) in people with motor neuron disease/amyotrophic lateral sclerosis

It is very uncertain whether radiotherapy changes adverse events, reported as "negative experiences" compared with botulinum toxin (very low certainty).

1 finding from 1 review

ISBCS vs DSBCS

Proportion of participants with endophthalmitis · people with bilateral age‐related cataracts (NRSs)
2 findings from 1 review

ISBCS vs DSBCS

Complications · people with bilateral age‐related cataracts (NRSs)

It is very uncertain whether ISBCS changes complications compared with DSBCS (very low certainty).

2 findings from 1 review

ISBCS vs DSBCS

Total costs per QALY · people with bilateral age‐related cataracts (NRSs)

The review found no eligible studies for this question.

2 findings from 1 review

ISBCS vs DSBCS

BCDVA · people with bilateral age‐related cataracts (NRSs)

The review found no eligible studies for this question.

2 findings from 1 review

ISBCS vs DSBCS

Patient‐reported outcome measures (PROMs) · people with bilateral age‐related cataracts (NRSs)

The review found no eligible studies for this question.

2 findings from 1 review

ISBCS vs DSBCS

Refraction NOT within 1.0 dioptres of target · people with bilateral age‐related cataracts (NRSs)

ISBCS showed no clear difference in refraction NOT within 1.0 dioptres of target compared with DSBCS (moderate certainty).

2 findings from 1 review

Autologous blood or PRP vs placebo at 3 months' follow‐up

Treatment success (> 25% improvement in pain or function) · lateral elbow pain

It is very uncertain whether autologous blood or PRP changes treatment success (> 25% improvement in pain or function) compared with placebo at 3 months' follow‐up (very low certainty).

1 finding from 1 review

Autologous blood or PRP vs placebo at 3 months' follow‐up

Adverse events (pain and swelling at injection site and limitation of elbow movement following injection) · lateral elbow pain

Autologous blood or PRP showed no clear difference in adverse events (pain and swelling at injection site and limitation… compared with placebo at 3 months' follow‐up (low certainty).

1 finding from 1 review

Minimally invasive parathyroidectomy vs bilateral neck exploration

Success rate (eucalcaemia) (a)

It is very uncertain whether minimally invasive parathyroidectomy changes success rate (eucalcaemia) (a) compared with bilateral neck exploration (very low certainty).

1 finding from 1 review

Minimally invasive parathyroidectomy vs bilateral neck exploration

Adverse effects: perioperative complications (number of events)

Minimally invasive parathyroidectomy may leads to lower total incidence of perioperative adverse events (number) compared with bilateral neck exploration (low certainty).

1 finding from 1 review