Adverse effect: Specific ‐ Death · people with psychosis‐induced aggression
1 finding from 1 review
Service outcomes: Not discharged ‐ by 4 hours · people with psychosis‐induced aggression
HALOPERIDOL + PROMETHAZINE showed no clear difference in service outcomes: Not discharged ‐ by 4 hours compared with BENZODIAZEPINES ‐ LORAZEPAM (high certainty).
1 finding from 1 review
Aggression · people with psychosis‐induced aggression
1 finding from 1 review
Economic outcomes: Cost of care · people with psychosis‐induced aggression
1 finding from 1 review
Tranquil or asleep: Not tranquil or asleep · people with psychosis‐induced aggression
HALOPERIDOL + PROMETHAZINE leads to higher tranquil or asleep: Not tranquil or asleep compared with BENZODIAZEPINES ‐ MIDAZOLAM (high certainty).
1 finding from 1 review
Global outcome ‐ need for restraint or seclusion · people with psychosis‐induced aggression
HALOPERIDOL + PROMETHAZINE showed no clear difference in global state: Needing restraints or seclusion‐ by 2 hours compared with BENZODIAZEPINES ‐ MIDAZOLAM (moderate certainty).
1 finding from 1 review
Adverse effect: Specific ‐ Death · people with psychosis‐induced aggression
1 finding from 1 review
Not discharged from hospital · people with psychosis‐induced aggression
HALOPERIDOL + PROMETHAZINE showed no clear difference in service outcomes: Not discharged ‐ compared with BENZODIAZEPINES ‐ MIDAZOLAM (high certainty).
1 finding from 1 review
Specific behavioursAggression · people with psychosis‐induced aggression
1 finding from 1 review
no estimate extracted
4 participants
GRADE not reported
Economic outcomes: Cost of care · people with psychosis‐induced aggression
1 finding from 1 review
Tranquil or asleep: Not tranquil or asleep ‐ by 30 mins · people with psychosis‐induced aggression
HALOPERIDOL + PROMETHAZINE showed no clear difference in tranquil or asleep: Not tranquil or asleep ‐ by 30 mins compared with ANTIPSYCHOTIC ‐ OLANZAPINE (high certainty).
1 finding from 1 review
Global state: Needing restraints or seclusion ‐ by 12 hours · people with psychosis‐induced aggression
HALOPERIDOL + PROMETHAZINE showed no clear difference in global state: Needing restraints or seclusion by 12 hours compared with ANTIPSYCHOTIC ‐ OLANZAPINE (low certainty).
1 finding from 1 review
Adverse effects/events ‐ extrapyramidal symptoms ‐ medium term Number of instances of extrapyramidal symptoms · psychosis‐induced aggression or agitation
Benzodiazepines may leads to lower adverse effects/events: extrapyramidal symptoms ‐ vs haloperidol ‐… compared with antipsychotics (low certainty).
1 finding from 1 review
Adverse effects: 1. Sedation · psychosis‐induced aggression or agitation
Benzodiazepines may leads to lower tranquillisation or asleep: sedation ‐ medium term ‐ lorazepam vs… compared with antihistamines plus antipsychotics (low certainty).
1 finding from 1 review
Tranquillisation or asleep: sedation ‐ medium term ‐ midazolam vs haloperidol + promethazineNumber of participants sedated · psychosis‐induced aggression or agitation
Benzodiazepines may leads to higher tranquillisation or asleep: sedation ‐ medium term ‐ midazolam vs… compared with antihistamines plus antipsychotics (low certainty).
1 finding from 1 review
Adverse effects: 1. Sedation · psychosis‐induced aggression or agitation
Benzodiazepines + antipsychotics showed no clear difference in tranquillisation or asleep: sedation ‐ medium term‐ + haloperidol ‐… compared with same enzodiazepines (low certainty).
1 finding from 1 review
Global state: no improvement ‐ + haloperidol ‐ medium term As defined in each study · psychosis‐induced aggression or agitation
Benzodiazepines + antipsychotics showed no clear difference in global state: no improvement ‐ + haloperidol ‐ medium term As… compared with same enzodiazepines (low certainty).
1 finding from 1 review
Global impression ‐ need for additional medication ‐ medium term Number of participants requiring additional medication · psychosis‐induced aggression or agitation
Benzodiazepines + antipsychotics showed no clear difference in global state: need for additional medication ‐ + haloperidol ‐… compared with same enzodiazepines (low certainty).
1 finding from 1 review
Adverse effects: any observed extrapyramidal symptoms ‐ short term (up to 6 months) · psychosis‐induced aggression or agitation
Benzodiazepines + antipsychotics showed no clear difference in adverse effects/events: extrapyramidal symptoms ‐ + haloperidol ‐… compared with same enzodiazepines (low certainty).
1 finding from 1 review
Adverse effects: 1. Sedation · psychosis‐induced aggression or agitation
It is very uncertain whether benzodiazepines + antipsychotics changes tranquillisation or asleep: sedation ‐ medium term ‐ +/vs… compared with same antipsychotics (very low certainty).
1 finding from 1 review