BENZODIAZEPINES + ANTIPSYCHOTICS vs SAME ANTIPSYCHOTICS: Adverse effects: 1. Sedation
It is very uncertain whether benzodiazepines + antipsychotics changes tranquillisation or asleep: sedation ‐ medium term ‐ +/vs… compared with same antipsychotics (very low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Benzodiazepines + antipsychotics vs same antipsychotics Tranquillisation or asleep: sedation ‐ medium term ‐ +/vs haloperidol Number of participants sedated · people with psychosis‐induced aggression or agitation It is very uncertain whether benzodiazepines + antipsychotics changes tranquillisation or asleep: sedation ‐ medium term ‐ +/vs… compared with same antipsychotics (very low certainty). Benzodiazepines for psychosis‐induced aggression or agitation (2017) · Cochrane Headline outcomes only | RR 1.75 [1.14, 2.67] | 3 studies · 172 participants | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Benzodiazepines for psychosis‐induced aggression or agitation 2017 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.