Intervention not reported
MD‐TRIPLE (Direct evidence; 2 RCTs; 2237 participants) · Adolescents and adults with symptomatic asthma Interventions: HD‐ICS/LABA, MD‐TRIPLE, HD‐TRIPLE Comparator (reference): Medium‐Dose…
1 finding from 1 review
Intervention not reported
HD‐TRIPLE (Direct evidence; 1 RCT; 1088 participants) · Adolescents and adults with symptomatic asthma Interventions: HD‐ICS/LABA, MD‐TRIPLE, HD‐TRIPLE Comparator (reference): Medium‐Dose…
1 finding from 1 review
Intervention not reported
MD‐ICS/LABA · Adolescents and adults with symptomatic asthma Interventions: HD‐ICS/LABA, MD‐TRIPLE, HD‐TRIPLE Comparator (reference): Medium‐Dose…
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Intervention not reported
Outcome№ of participants(studies)
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Intervention not reported
ACQ responders at 6 months ‐ HD‐ICS/LABA vs MD‐ICS/LABA№ of participants: 3700(3 RCTs)
The intervention showed no clear difference in ACQ responders at 6 months ‐ HD‐ICS/LABA vs MD‐ICS/LABA№ of… (moderate certainty).
1 finding from 1 review
Rate of exacerbations requiring systemic corticosteroids · mild asthma
As‐required FABA/ICS inhalers leads to lower asthma exacerbation requiring systemic steroid compared with as‐required FABA inhalers (high certainty).
1 finding from 1 review
Inhaled steroid dose · mild asthma
1 finding from 1 review
Total systemic steroid dose · mild asthma
1 finding from 1 review
Adverse events · mild asthma
As‐required FABA/ICS inhalers showed no clear difference in adverse events compared with regular inhaled steroid (moderate certainty).
1 finding from 1 review
Hospital admission, ED and urgent care visits · mild asthma
As‐required FABA/ICS inhalers may leads to lower hospital admission, ED and urgent care visits compared with as‐required FABA inhalers (low certainty).
1 finding from 1 review
Asthma control · mild asthma
1 finding from 1 review
Inhaled steroid dose · mild asthma
1 finding from 1 review
Total systemic steroid dose · mild asthma
1 finding from 1 review
Adverse events · mild asthma
As‐required FABA/ICS inhalers probably leads to lower adverse events compared with as‐required FABA inhalers (moderate certainty).
1 finding from 1 review
Rate of exacerbations requiring systemic corticosteroids · mild asthma
As‐required FABA/ICS inhalers showed no clear difference in exacerbations requiring systemic steroid compared with regular inhaled steroid (low certainty).
1 finding from 1 review
Hospital admission, ED and urgent care visits · mild asthma
As‐required FABA/ICS inhalers may leads to lower hospital admission, ED and urgent care visits compared with regular inhaled steroid (low certainty).
1 finding from 1 review
Asthma control · mild asthma
1 finding from 1 review
Moderate to severe exacerbations: high‐risk population · chronic obstructive pulmonary disease with predicted FEV1 of less than 80%
LABA/LAMA showed no clear difference in moderate to severe exacerbations: high‐risk population compared with LABA/ICS (moderate certainty).
1 finding from 1 review
Severe exacerbations: low‐risk population · chronic obstructive pulmonary disease with predicted FEV1 of less than 80%
LABA/LAMA showed no clear difference in severe exacerbations: low‐risk population compared with LAMA (moderate certainty).
1 finding from 1 review
Pneumonia: high‐risk population · chronic obstructive pulmonary disease with predicted FEV1 of less than 80%
LABA/LAMA showed no clear difference in pneumonia: high‐risk population compared with LAMA (moderate certainty).
1 finding from 1 review