Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

239 questions · 278 findings · 28 reviews · Oral Health

No studies found 45 · 16.2%GRADE not reported 146 · 52.5%Very low 64 · 23%Low 14 · 5%Moderate 5 · 1.8%High 4 · 1.4%

Amine fluoride/stannous fluoride (AmF/SnF2) mouthwash vs Chlorhexidine mouthwash

Staining index · Adults with dental implants and healthy peri-implant soft tissues at baseline

Amine fluoride/stannous fluoride (AmF/SnF2) mouthwash showed no clear difference in staining index compared with chlorhexidine mouthwash; GRADE not reported.

1 finding from 1 review

Hyaluronic acid gel (brushing) vs Chlorhexidine, 0.2% to 2% (solution or gel)

Plaque · Adults with dental implants and healthy peri-implant soft tissues at baseline

Hyaluronic acid gel (brushing) showed no clear difference in plaque compared with chlorhexidine gel (brushing); GRADE not reported.

1 finding from 1 review

Amine fluoride/stannous fluoride (AmF/SnF2) mouthwash vs Chlorhexidine mouthwash

Change in taste · Adults with dental implants and healthy peri-implant soft tissues at baseline

Amine fluoride/stannous fluoride (AmF/SnF2) mouthwash led to lower change in taste compared with chlorhexidine mouthwash; GRADE not reported.

1 finding from 1 review

Amine fluoride/stannous fluoride (AmF/SnF2) mouthwash vs Chlorhexidine mouthwash

Implant failure · Adults with dental implants and healthy peri-implant soft tissues at baseline

Amine fluoride/stannous fluoride (AmF/SnF2) mouthwash showed no clear difference in implant failure compared with chlorhexidine mouthwash; GRADE not reported.

1 finding from 1 review

Mechanical debridement plus topical minocycline vs Mechanical debridement plus chlorhexidine gel

Change in probing pocket depth (PPD) · Adults with dental implants and peri-implant mucositis at baseline

Mechanical debridement plus topical minocycline showed no clear difference in change in probing pocket depth compared with mechanical debridement plus chlorhexidine gel; GRADE not reported.

1 finding from 1 review

Amine fluoride/stannous fluoride (AmF/SnF2) mouthwash vs Chlorhexidine mouthwash

Patient satisfaction (desire for future use) · Adults with dental implants and healthy peri-implant soft tissues at baseline

Amine fluoride/stannous fluoride (AmF/SnF2) mouthwash led to higher patient satisfaction (desire for future use) compared with chlorhexidine mouthwash; GRADE not reported.

1 finding from 1 review

Mechanical debridement plus topical minocycline vs Mechanical debridement plus chlorhexidine gel

Change in probing pocket depth (worst sites) · Adults with dental implants and peri-implant mucositis at baseline

Mechanical debridement plus topical minocycline showed no clear difference in change in probing pocket depth (worst sites) compared with mechanical debridement plus chlorhexidine gel; GRADE not reported.

1 finding from 1 review

Hyaluronic acid gel (brushing) vs Chlorhexidine, 0.2% to 2% (solution or gel)

Change in probing pocket depth (PPD) · Adults with dental implants and healthy peri-implant soft tissues at baseline

Hyaluronic acid gel (brushing) showed no clear difference in change in probing pocket depth compared with chlorhexidine gel (brushing); GRADE not reported.

1 finding from 1 review

Mechanical debridement plus topical minocycline vs Mechanical debridement plus chlorhexidine gel

Soreness in the gums · Adults with dental implants and peri-implant mucositis at baseline

Mechanical debridement plus topical minocycline showed no clear difference in soreness in the gums compared with mechanical debridement plus chlorhexidine gel; GRADE not reported.

1 finding from 1 review

Placebo rinse vs Pre-treatment (baseline, same group)

Lactobacillus count (pre- vs post-treatment) · Medically healthy individuals (adults and children, 6-60 years)

Placebo rinse did not significantly change Lactobacillus counts relative to baseline; not GRADE-rated.

1 finding from 1 review

Salvadora persica (miswak) mouthrinse vs Pre-treatment (baseline, same group)

Lactobacillus count (pre- vs post-treatment) · Medically healthy individuals (adults and children, 6-60 years)

Salvadora persica rinse reduced Lactobacillus counts relative to baseline; not GRADE-rated.

1 finding from 1 review

Salvadora persica (miswak) mouthrinse vs Placebo rinse

Lactobacillus count (CFU/mL) · Medically healthy individuals (adults and children, 6-60 years)

Salvadora persica rinse reduced Lactobacillus counts more than placebo (favours Salvadora persica); not GRADE-rated.

1 finding from 1 review

Salvadora persica (miswak) mouthrinse vs Pre-treatment (baseline, same group)

Streptococcus mutans count · Medically healthy individuals (adults and children, 6-60 years)

Salvadora persica rinse reduced Streptococcus mutans counts relative to baseline; not GRADE-rated.

1 finding from 1 review

Salvadora persica (miswak) mouthrinse vs Placebo rinse

Streptococcus mutans count · Medically healthy individuals (adults and children, 6-60 years)

Salvadora persica rinse reduced Streptococcus mutans counts more than placebo (favours Salvadora persica); not GRADE-rated.

1 finding from 1 review

Salvadora persica (miswak) mouthrinse vs Placebo rinse

Plaque · Medically healthy individuals (adults and children, 6-60 years)

Salvadora persica rinse reduced plaque more than placebo (favours Salvadora persica); certainty not GRADE-rated (Shekelle grade Ia).

1 finding from 1 review

Salvadora persica (miswak) mouthrinse vs Pre-treatment (baseline, same group)

Plaque · Medically healthy individuals (adults and children, 6-60 years)

Salvadora persica rinse reduced plaque relative to its own baseline; not GRADE-rated.

1 finding from 1 review

Placebo rinse vs Pre-treatment (baseline, same group)

Streptococcus mutans count · Medically healthy individuals (adults and children, 6-60 years)

Placebo rinse did not significantly change Streptococcus mutans counts relative to baseline; not GRADE-rated.

1 finding from 1 review