Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,005 questions · 1,053 findings · 151 reviews · Headline outcomes only

No studies found 275 · 26.1%GRADE not reported 150 · 14.2%Very low 271 · 25.7%Low 215 · 20.4%Moderate 105 · 10%High 37 · 3.5%

Bilateral lateral rectus recession vs lateral rectus recession and medial rectus resection

Minor adverse events Defined as any adverse event within 8 weeks of surgery that does not require further intervention · people with intermittent exotropia, aged 3 to < 11 years

Bilateral lateral rectus recession showed no clear difference in minor adverse events Defined as any adverse event within 8 weeks of… compared with unilateral lateral rectus recession with medial rectus resection (low certainty).

1 finding from 1 review

Complex information, support and training interventions vs information only

Leaving the study early · Informal caregivers of people with dementia

Complex information, support and training interventions probably leads to higher dropouts for any reason compared with information provision only (moderate certainty).

1 finding from 1 review

Complex information, support and training interventions vs inactive control (usual care care, attention control, waitlist)

Leaving the study early · Informal caregivers of people with dementia

Complex information, support and training interventions showed no clear difference in dropouts for any reason compared with usual treatment, waiting list or attention control informations (low certainty).

1 finding from 1 review

Any cranberry product vs placebo or control

Symptomatic, culture‐verified UTI People with a susceptibility to a UTI due to an intervention · preventing UTI

Any cranberry product may leads to lower symptomatic, culture‐verified UTI People with a susceptibility to a… compared with placebo or control (low certainty).

1 finding from 1 review

Intermittent iron supplementation (alone or with any other micronutrients) vs no supplementation or placebo

All‐cause morbidity · adolescent and adult menstruating women

Intermittent iron supplementation (alone or with any other… showed no clear difference in all‐cause morbidity (the most frequent event associated with the… compared with no supplementation or placebo (low certainty).

1 finding from 1 review

Intervention not reported

Finding 16. Accessible, sustainable interventions and finding the right type of exercise were all identified as important. For many women and men with bipolar disorder, the right type of exercise was walking. · s where they do not wish or feel the need to participate in physical activity.
1 finding from 1 review

Lamotrigine vs lithium

Withdrawal from treatment due to any reason, 6‐12 months after intervention initiation (long term) · bipolar disorder

Lamotrigine showed no clear difference in withdrawal from treatment due to any reason, 6‐12 months after… compared with lithium (moderate certainty).

1 finding from 1 review