Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

285 questions · 290 findings · 75 reviews · Headline outcomes only

No studies found 81 · 27.9%GRADE not reported 18 · 6.2%Very low 91 · 31.4%Low 62 · 21.4%Moderate 32 · 11%High 6 · 2.1%

Early discontinuation of antibiotic treatment vs treatment until neutropenia resolution

Bacteraemia · febrile neutropenia

It is very uncertain whether early discontinuation of antibiotic treatment changes any bacteraemia compared with treatment until neutropenia resolution (very low certainty).

1 finding from 1 review

RISPERIDONE vs OLANZAPINE

Leaving the study early · people with both severe mental illness and substance misuse

It is very uncertain whether RISPERIDONE changes leaving study early: any reason compared with OLANZAPINE ‒ short‐ and long‐term data (very low certainty).

1 finding from 1 review

RISPERIDONE vs QUETIAPINE

Leaving the study early · people with both severe mental illness and substance misuse

RISPERIDONE showed no clear difference in leaving the study early: 1. any reason, long term (>12 months) compared with QUETIAPINE ‒ short‐ and long‐term data (low certainty).

1 finding from 1 review

RISPERIDONE vs ZIPRASIDONE ‒ long‐term data (> 12 months)

Leaving the study early · people with both severe mental illness and substance misuse

RISPERIDONE showed no clear difference in leaving the study early: any reason compared with ZIPRASIDONE ‒ long‐term data (> 12 months) (low certainty).

1 finding from 1 review

RISPERIDONE vs CLOZAPINE ‐ all data short term

Adverse effects: any observed extrapyramidal symptoms ‐ short term (up to 6 months) · people with both severe mental illness and substance misuse

It is very uncertain whether RISPERIDONE changes adverse effects. 1. Movement disorders ‐ any extrapyramidal compared with CLOZAPINE ‐ all data short term (very low certainty).

1 finding from 1 review

RISPERIDONE vs CLOZAPINE ‐ all data short term

Leaving the study early · people with both severe mental illness and substance misuse

It is very uncertain whether RISPERIDONE changes leaving the study early ‒ any reason compared with CLOZAPINE ‐ all data short term (very low certainty).

1 finding from 1 review

Intervention not reported

Number of participants who received additional medical consultant (for any reasons) · Women undergoing excision of the cervical transformation zone for cervical neoplasia

The intervention showed no clear difference in number of participants who received additional medical consultant… (low certainty).

1 finding from 1 review

Intervention not reported

Number of subjects who develop any adverse event (42 days to 10 months) · adults with asymptomatic bacteriuria

The intervention probably leads to higher number of subjects who develop any adverse event (42 days to 10… (moderate certainty).

1 finding from 1 review

Antibiotics vs control ‐ primary outcomes

Prevention ‐ any AOM or CSOM during intervention · patients with the prevention of acute and chronic suppurative otitis media in children

Antibiotic probably leads to lower prevention ‐ any AOM or CSOM during intervention compared with control ‐ primary outcomes (moderate certainty).

1 finding from 1 review

Antibiotics vs control ‐ secondary outcomes

Side effects ‐ any clinical side effects during intervention · patients with the prevention of acute and chronic suppurative otitis media in children

Antibiotic showed no clear difference in side effects ‐ any clinical side effects during intervention compared with control ‐ secondary outcomes (moderate certainty).

1 finding from 1 review