Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

275 questions · 299 findings · 21 reviews · Oral and maxillofacial surgery

No studies found 50 · 16.7%GRADE not reported 207 · 69.2%Very low 17 · 5.7%Low 20 · 6.7%Moderate 5 · 1.7%High 0 · 0%

Zinc oxide and eugenol (ZOE) vs Alvogyl (old formulation)

Success rate (radiographically‐assessed healing of cyst healing based on the Neer/Cole rating system) · Adults (>18 years) with established dry socket following permanent tooth extraction
1 finding from 1 review

Recombinant bovine fibroblast growth factor gel vs control

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

Recombinant bovine fibroblast growth factor gel led to lower presence of dry socket compared with control; GRADE not reported.

1 finding from 1 review

Chlorhexidine rinse (0.12% and 0.2%, pre- and post-extraction) vs placebo or no treatment

Adverse events · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)
1 finding from 1 review
  • Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes
    Follow-up: median 7 days
    3 trials reported no adverse events. 1 study reported adverse events (alterations in taste, bad taste, staining) in 24/62 in chlorhexidine group versus 0/40 in placebo group, Peto OR = 8.42 (95% CI 3.31 to 21.39). A…
    6 studies
    GRADE not reported

Iodine tampon vs Saline irrigation (monoject syringe)

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)
1 finding from 1 review

Alvogyl vs no treatment

Pain (VAS) · Adults (>18 years) with established dry socket following permanent tooth extraction
1 finding from 1 review

Chlorhexidine rinse (0.2%) pre- and post-extraction vs Chlorhexidine rinse (0.2%) post-extraction only

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

Chlorhexidine rinse (0.2%) pre- and post-extraction showed no clear difference in presence of dry socket compared with chlorhexidine rinse (0.2%) post-extraction only; GRADE not reported.

1 finding from 1 review

Metronidazole gel 25% (local antibiotic) vs Placebo gel

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

Metronidazole gel (25%, intrasocket) showed no clear difference in presence of dry socket compared with placebo gel; GRADE not reported.

1 finding from 1 review

Herbal mouthrinse vs Chlorhexidine 0.2% mouthrinse

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

Herbal mouthrinse showed no clear difference in presence of dry socket compared with chlorhexidine 0.2% mouthrinse; GRADE not reported.

1 finding from 1 review

Autologous platelet‐rich plasma vs placebo or no treatment

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

It is very uncertain whether platelet rich plasma changes presence of dry socket compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Artemisia desertorum spreng (Yunnan) vs placebo

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

Artemisia desertorum spreng (Yunnan) showed no clear difference in presence of dry socket compared with placebo; GRADE not reported.

1 finding from 1 review