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Evidence found and GRADE certainty

704 questions · 710 findings · 81 reviews · Headline outcomes only

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No studies found 227 · 32%GRADE not reported 38 · 5.4%Very low 178 · 25.1%Low 178 · 25.1%Moderate 80 · 11.3%High 9 · 1.3%

Conventional occlusion vs atropine penalization

Ocular alignment (different measures and time points reported in the included studies) Assessed at different time points (17 weeks, 24 months, or cessation of treatment) and by the proportions of participants who developed strabismus, showed chang... · Participants of any age with either unilateral strabismic, anisometropic, or mixed (strabismic‐refractive) amblyopia; deprivation…
1 finding from 1 review

Conventional occlusion vs atropine penalization

Stereo acuity (different measures and time points reported in the included studies) Assessed at different time points (17 weeks, 6 months, 2 years, or at cessation of treatment) and using different measures (TNO stereo test, Titmus fly test, Rando... · Participants of any age with either unilateral strabismic, anisometropic, or mixed (strabismic‐refractive) amblyopia; deprivation…
1 finding from 1 review

Conventional occlusion vs atropine penalization

Quality of life (different measures and time points reported in the included studies) Assessed at different time points (17 weeks or 6 months) by patient preference or the Amblyopia Treatment Index questionnaire. · Participants of any age with either unilateral strabismic, anisometropic, or mixed (strabismic‐refractive) amblyopia; deprivation…
1 finding from 1 review

Conventional occlusion vs atropine penalization

Adverse events (reported occurrence of: mild reduction in the visual acuity of the sound eye not requiring treatment; light sensitivity; skin, lid, or conjunctival irritation) Assessed at different time points (17 weeks or 2 years). · Participants of any age with either unilateral strabismic, anisometropic, or mixed (strabismic‐refractive) amblyopia; deprivation…
1 finding from 1 review

Summary of findings: Specialist inpatient care for weight restoration vs active outpatient or combination brief hospital/outpatient care

Weight or BMI (at end of 12 months from the start of treatment) · participants with anorexia nervosa

Summary of findings: Specialist inpatient care for weight restoration showed no clear difference in weight or BMI (at end of 12 months from the start of treatment) compared with active outpatient or combination brief hospital/outpatient care (low certainty).

1 finding from 1 review

Summary of findings: Specialist inpatient care for weight restoration vs active outpatient or combination brief hospital/outpatient care

Secondary outcome: acceptability of treatment · participants with anorexia nervosa

It is very uncertain whether summary of findings: Specialist inpatient care for weight restoration changes acceptability: number of participants who completed treatment (at… compared with active outpatient or combination brief hospital/outpatient care (very low certainty).

1 finding from 1 review

Cognitive training vs active control

Satisfaction with treatment: 1. Leaving the study early ‐ long term · people in the prodromal stage of psychosis

It is very uncertain whether group C other: cognitive training changes satisfaction with treatment: leaving the study early Endpoint data… compared with active control (tablet games) (very low certainty).

1 finding from 1 review

Timer watch plus standard urotherapy vs urotherapy alone

Resolution of daytime urinary incontinence · children aged 5 to 14 years with overactive bladder and at least one episode of daytime urinary incontinence per week

It is very uncertain whether timer watch plus standard urotherapy changes resolution of daytime urinary incontinence after 3 months of treatment compared with standard urotherapy alone (very low certainty).

1 finding from 1 review

Voiding education with uroflowmetry and feedback vs anticholinergics

Resolution of daytime urinary incontinence · children aged 6 to 12 years with overactive bladder with urge incontinence

It is very uncertain whether voiding education with uroflowmetry and feedback changes resolution of daytime urinary incontinence at 12 months after 6… compared with anticholinergics (very low certainty).

1 finding from 1 review

Non‐trauma‐focused psychological intervention for PTSD and SUD or PTSD only vs psychological interventions

Drug or alcohol use, or both following treatment completion ‐ Individual‐based intervention · Individuals with post‐traumatic stress disorder and comorbid substance use disorder
1 finding from 1 review

Non‐trauma‐focused psychological intervention for PTSD and SUD or PTSD only vs psychological interventions

Treatment completers · Individuals with post‐traumatic stress disorder and comorbid substance use disorder

It is very uncertain whether non‐trauma‐focused psychological intervention for PTSD and SUD or… changes treatment completers compared with active psychological intervention (very low certainty).

1 finding from 1 review

Trauma‐focused psychological intervention vs psychological interventions

Treatment completers · Individuals with post‐traumatic stress disorder and comorbid substance use disorder

Trauma‐focused psychological intervention showed no clear difference in treatment completers compared with active psychological intervention (low certainty).

1 finding from 1 review