Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,072 questions · 4,237 findings · 447 reviews · Headline outcomes only

No studies found 946 · 22.3%GRADE not reported 257 · 6.1%Very low 1,121 · 26.5%Low 1,207 · 28.5%Moderate 568 · 13.4%High 138 · 3.3%

Summary of findings ‐ Erector spinae plane block vs paravertebral block

Rates of block‐related adverse events · adults undergoing surgery with general anaesthesia

Summary of findings ‐ Erector spinae plane block probably leads to lower rates of block‐related adverse events compared with paravertebral block (moderate certainty).

1 finding from 1 review

Summary of findings ‐ Erector spinae plane block vs transversus abdominis plane block

Rates of block‐related adverse events · adults undergoing surgery with general anaesthesia

Summary of findings ‐ Erector spinae plane block showed no clear difference in rates of block‐related adverse events compared with transversus abdominis plane block (low certainty).

1 finding from 1 review

Botulinum toxin vs surgery

Improved or corrected strabismusa at 6 or 12 months · adults and children with strabismus

Botulinum toxin may leads to lower improved or corrected strabismusa at 6 or 12 months compared with surgery (low certainty).

1 finding from 1 review

Botulinum toxin vs surgery

Proportion of participants who achieved binocular single vision at 6 or 12 months · adults and children with strabismus

Botulinum toxin showed no clear difference in proportion of participants who achieved binocular single vision at 6… compared with surgery (low certainty).

1 finding from 1 review

Remote ischaemic preconditioning (RIPC) vs no RIPC

Perioperative mortality · people undergoing elective major vascular surgery

Remote ischaemic preconditioning (RIPC) showed no clear difference in perioperative mortality (within 1 month after operation) compared with no RIPC (moderate certainty).

1 finding from 1 review

Remote ischaemic preconditioning (RIPC) vs no RIPC

Myocardial infarction (0 to 30 days) · people undergoing elective major vascular surgery

Remote ischaemic preconditioning (RIPC) showed no clear difference in myocardial infarction (within 1 month after operation) compared with no RIPC (moderate certainty).

1 finding from 1 review

Remote ischaemic preconditioning (RIPC) vs no RIPC

Renal impairment (within 1 month after operation) · people undergoing elective major vascular surgery

Remote ischaemic preconditioning (RIPC) showed no clear difference in renal impairment (within 1 month after operation) compared with no RIPC (moderate certainty).

1 finding from 1 review