Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,776 questions · 7,311 findings · 959 reviews · Headline outcomes only

No studies found 1,498 · 20.5%GRADE not reported 303 · 4.1%Very low 1,839 · 25.2%Low 1,991 · 27.2%Moderate 1,277 · 17.5%High 403 · 5.5%

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Infliximab vs biosimilar

Loss of clinical response (at 52 weeks, HBI change from baseline of less than 4 points and a total score of less than 7 points) · patients with Crohn's disease (with mixed/low disease activity at baseline)

Infliximab may leads to higher loss of clinical response (at 52 weeks, HBI change from baseline of… compared with biosimilar (low certainty).

1 finding from 1 review

Anticipated high responders: higher vs lower dose of FSH

IU vs 100 IU · women undergoing IVF/ICSI who are anticipated to have a hyper‐response to stimulation based on at least one ORT measure

Anticipated high responders: higher showed no clear difference in IU vs 100 IU compared with lower dose of FSH (low certainty).

1 finding from 1 review

Anticipated normal responders: higher vs lower dose of FSH

IU vs 100 IU · women undergoing IVF/ICSI who are anticipated to have a normal response to stimulation based on at least one ORT measure

Anticipated normal responders: higher showed no clear difference in IU vs 100 IU compared with lower dose of FSH (low certainty).

1 finding from 1 review

Anticipated normal responders: higher vs lower dose of FSH

225/200 IU vs 150 IU · women undergoing IVF/ICSI who are anticipated to have a normal response to stimulation based on at least one ORT measure

Anticipated normal responders: higher showed no clear difference in 225/200 IU vs 150 IU compared with lower dose of FSH (low certainty).

1 finding from 1 review

Anticipated normal responders: higher vs lower dose of FSH

IU vs 225 IU · women undergoing IVF/ICSI who are anticipated to have a normal response to stimulation based on at least one ORT measure

Anticipated normal responders: higher showed no clear difference in IU vs 225 IU compared with lower dose of FSH (low certainty).

1 finding from 1 review

nHFV vs nIPPV following failure of initial non‐invasive respiratory support

Mortality before hospital discharge · ventilated preterm infants with failure of initial non‐invasive respiratory support

nHFV showed no clear difference in mortality before hospital discharge compared with nIPPV following failure of initial non‐invasive respiratory support (low certainty).

1 finding from 1 review

nHFV vs nIPPV following failure of initial non‐invasive respiratory support

Endotracheal intubation To discharge · ventilated preterm infants with failure of initial non‐invasive respiratory support

It is very uncertain whether nHFV changes endotracheal intubation To discharge compared with nIPPV following failure of initial non‐invasive respiratory support (very low certainty).

1 finding from 1 review

nHFV vs nIPPV following failure of initial non‐invasive respiratory support

Chronic lung disease · ventilated preterm infants with failure of initial non‐invasive respiratory support

nHFV showed no clear difference in chronic lung disease compared with nIPPV following failure of initial non‐invasive respiratory support (low certainty).

1 finding from 1 review

nHFV vs nIPPV following failure of initial non‐invasive respiratory support

Intraventricular haemorrhage, Papile grade 3/4 · ventilated preterm infants with failure of initial non‐invasive respiratory support

nHFV showed no clear difference in intraventricular haemorrhage, Papile grade 3/4 compared with nIPPV following failure of initial non‐invasive respiratory support (low certainty).

1 finding from 1 review