Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,801 questions · 4,079 findings · 473 reviews

No studies found 669 · 16.4%GRADE not reported 852 · 20.9%Very low 738 · 18.1%Low 903 · 22.1%Moderate 716 · 17.6%High 201 · 4.9%

Summary of findings table ‐ Enteral tube feeding vs intravenous fluids

Successful insertion of intravenous fluid/enteral tube fluid at first attempt · health problem or population

Summary of findings table ‐ Enteral tube feeding probably leads to higher successful insertion of intravenous fluid/enteral tube fluid at… compared with intravenous fluids (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Enteral tube feeding vs intravenous fluids

Change in modality of fluid therapy · health problem or population

Summary of findings table ‐ Enteral tube feeding probably leads to lower change in modality of fluid therapy compared with intravenous fluids (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Enteral tube feeding vs intravenous fluids

Local complications (overall): IV line bruising, soreness, infection, epistaxis, nasal trauma, others · health problem or population

Summary of findings table ‐ Enteral tube feeding showed no clear difference in local complications (overall): IV line bruising, soreness,… compared with intravenous fluids (moderate certainty).

1 finding from 1 review

Gum chewing (sugar-free) vs Pooled controls: no gum, placebo/control gum, probiotic, or fluoride varnish

Streptococcus mutans load in the oral cavity (saliva and/or dental plaque) · Adults and children (general population)

In a sensitivity analysis assuming a 0.95 baseline-to-endpoint correlation for the sugar-free gum arm, the effect remained significant (SMD -0.55, 95% CI -0.80 to -0.30; 13 trials, I2 73%); certainty not formally graded.

2 findings from 1 review

Systemic sclerosis (SSc / scleroderma) vs SSc-free individuals (controls)

DMFT/DMFS index (dental caries experience) · Adults (general and hospital populations assessed in case-control studies)

No statistically significant difference in DMFT index between SSc patients and controls (SMD -0.03, CI includes 0); certainty ungraded.

1 finding from 1 review

Systemic sclerosis (SSc / scleroderma) vs SSc-free individuals (controls)

Maximal mouth opening (interincisal distance) · Adults (general and hospital populations assessed in case-control studies)

Systemic sclerosis patients have significantly reduced mouth opening compared with controls (SMD -1.06); certainty ungraded.

1 finding from 1 review

Systemic sclerosis (SSc / scleroderma) vs SSc-free individuals (controls)

Number of teeth · Adults (general and hospital populations assessed in case-control studies)

No statistically significant difference in number of teeth between SSc patients and controls (SMD -0.95, CI includes 0); certainty ungraded.

1 finding from 1 review

Intervention not reported

Dental caries prevalence · General population (children and adults) in East Africa

Caries prevalence in mixed dentition (6-12 years) was 41.3% (95% CI 33.5 to 49.2); certainty not graded.

1 finding from 1 review

Systemic sclerosis (SSc / scleroderma) vs SSc-free individuals (controls)

Mean number of missing teeth in OC cases vs controls · Adults (general and hospital populations assessed in case-control studies)

No statistically significant difference in number of missing teeth between SSc patients and controls (SMD 0.55, CI includes 0); certainty ungraded.

1 finding from 1 review

Sealing using sealant materials vs Non-selective carious tissue removal and conventional restoration (CR)

Lesion progression · Children and/or adults with permanent or primary teeth, vital (sensitive) pulps, and cavitated or dentine carious lesions conventionally…
1 finding from 1 review

Hall technique vs Non-restorative cavity control (NRCC)

Efficiency, costs or cost-effectiveness · Children and/or adults with permanent or primary teeth, vital (sensitive) pulps, and cavitated or dentine carious lesions conventionally…
1 finding from 1 review

Sealing using sealant materials vs no treatment

Lesion progression · Children and/or adults with permanent or primary teeth, vital (sensitive) pulps, and cavitated or dentine carious lesions conventionally…
1 finding from 1 review

Systemic sclerosis (SSc / scleroderma) vs SSc-free individuals (controls)

Percentage of bleeding on probing (BOP) · Adults (general and hospital populations assessed in case-control studies)

No statistically significant difference in bleeding on probing between SSc patients and controls (SMD 1.05, CI includes 0); certainty ungraded.

1 finding from 1 review

Systemic sclerosis (SSc / scleroderma) vs SSc-free individuals (controls)

Periodontitis (clinical attachment loss) · Adults (general and hospital populations assessed in case-control studies)

Attachment loss is significantly increased in systemic sclerosis patients (SMD 2.58) with very high heterogeneity; certainty ungraded.

1 finding from 1 review

Systemic sclerosis (SSc / scleroderma) vs SSc-free individuals (controls)

Patient outcomes: mean number of filled teeth per 0- to 15-year-old · Adults (general and hospital populations assessed in case-control studies)

No statistically significant difference in number of filled teeth between SSc patients and controls (SMD -0.12, CI includes 0); certainty ungraded.

1 finding from 1 review

Hall technique vs Non-restorative cavity control (NRCC)

Failure of therapy · Children and/or adults with permanent or primary teeth, vital (sensitive) pulps, and cavitated or dentine carious lesions conventionally…

It is very uncertain whether hall Technique (sealing with a preformed metal crown) changes failure of therapy compared with non-restorative cavity control (NRCC) (very low certainty).

1 finding from 1 review