What do systematic reviews say?

COE with blood/salivary (biomarker) analysis vs Conventional oral examination (COE) alone

The review found no eligible studies for this question.

• Clinical assessment for the detection of oral cavity cancer and potentially malignant disorders in apparently healthy… 2021 · Cochrane All outcomes
  No eligible studies; planned comparative analysis (COE vs COE with blood/salivary analysis) not populated in this version.
  0 studies
  No studies found

Vital staining (e.g. toluidine blue, tolonium chloride) vs Surgical or punch biopsy with histological assessment

• Diagnostic tests for oral cancer and potentially malignant disorders in patients presenting with clinically evident… 2021 · Cochrane All outcomes
  Sensitivity 0.86 [0.79, 0.90]
  20 studies
  Low

Concomitant (concurrent) chemoradiotherapy vs Radiotherapy alone

Concomitant (concurrent) chemoradiotherapy led to lower locoregional control, concurrent chemoradiotherapy (platinum +… compared with radiotherapy alone (non-resectable tumours); GRADE not reported.

• Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy 2021 · Cochrane All outcomes
  RR 0.75 [0.61, 0.93]
  3 studies
  GRADE not reported

Combined index tests (e.g. vital staining plus light-based detection or cytology) vs Surgical or punch biopsy with histological assessment

• Diagnostic tests for oral cancer and potentially malignant disorders in patients presenting with clinically evident… 2021 · Cochrane All outcomes
  Specificity 0.71 [0.53, 0.84]
  9 studies
  Very low

Surgery +/- radiotherapy + (adjuvant) chemotherapy vs Surgery +/- radiotherapy alone (observation or adjuvant radiotherapy only)

Surgery +/- radiotherapy + (adjuvant) chemotherapy showed no clear difference in overall survival, adjuvant chemotherapy vs observation alone… compared with surgery +/- radiotherapy alone (observation or adjuvant radiotherapy… (moderate certainty).

• Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy 2021 · Cochrane All outcomes
  HR 0.95 [0.73, 1.22]
  5 studies · 353 participants
  Moderate

Dietary advice vs oral nutritional supplements

The review found no eligible studies for this question.

• Dietary advice with or without oral nutritional supplements for disease‐related malnutrition in adults 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Dietary advice vs oral nutritional supplements

The review found no eligible studies for this question.

• Dietary advice with or without oral nutritional supplements for disease‐related malnutrition in adults 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Dietary advice vs oral nutritional supplements

• Dietary advice with or without oral nutritional supplements for disease‐related malnutrition in adults 2021 · Cochrane Headline outcomes only
  no estimate extracted
  9 studies · 517 participants
  Low

Dietary advice vs oral nutritional supplements

The review found no eligible studies for this question.

• Dietary advice with or without oral nutritional supplements for disease‐related malnutrition in adults 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Dietary advice vs oral nutritional supplements

• Dietary advice with or without oral nutritional supplements for disease‐related malnutrition in adults 2021 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 283 participants
  Low

Dietary advice vs dietary advice plus oral nutritional supplements

Dietary advice showed no clear difference in mortality compared with dietary advice plus oral nutritional supplements (low certainty).

• Dietary advice with or without oral nutritional supplements for disease‐related malnutrition in adults 2021 · Cochrane Headline outcomes only
  RR 0.92 [0.47, 1.8]
  10 studies · 777 participants
  Low

Dietary advice vs dietary advice plus oral nutritional supplements

Dietary advice may leads to higher number of people admitted or re‐admitted to hospital compared with dietary advice plus oral nutritional supplements (low certainty).

• Dietary advice with or without oral nutritional supplements for disease‐related malnutrition in adults 2021 · Cochrane Headline outcomes only
  RR 1.7 [1.04, 2.77]
  1 study · 114 participants
  Low

Dietary advice vs dietary advice plus oral nutritional supplements

• Dietary advice with or without oral nutritional supplements for disease‐related malnutrition in adults 2021 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 202 participants
  Low

Dietary advice vs dietary advice plus oral nutritional supplements

Dietary advice may leads to lower complications compared with dietary advice plus oral nutritional supplements (low certainty).

• Dietary advice with or without oral nutritional supplements for disease‐related malnutrition in adults 2021 · Cochrane Headline outcomes only
  RR 0.75 [0.56, 0.99]
  3 studies · 317 participants
  Low

Dietary advice vs dietary advice plus oral nutritional supplements

• Dietary advice with or without oral nutritional supplements for disease‐related malnutrition in adults 2021 · Cochrane Headline outcomes only
  no estimate extracted
  14 studies · 931 participants
  Low

Dietary advice vs dietary advice plus oral nutritional supplements

• Dietary advice with or without oral nutritional supplements for disease‐related malnutrition in adults 2021 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 187 participants
  Low

Dietary advice vs dietary advice plus oral nutritional supplements

• Dietary advice with or without oral nutritional supplements for disease‐related malnutrition in adults 2021 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 321 participants
  Low

Dietary advice vs oral nutritional supplements

Dietary advice showed no clear difference in mortality compared with oral nutritional supplements (low certainty).

• Dietary advice with or without oral nutritional supplements for disease‐related malnutrition in adults 2021 · Cochrane Headline outcomes only
  RR 0.66 [0.34, 1.26]
  8 studies · 576 participants
  Low

Dietary advice vs oral nutritional supplements

Dietary advice showed no clear difference in number of people admitted or re‐admitted to hospital compared with oral nutritional supplements (low certainty).

• Dietary advice with or without oral nutritional supplements for disease‐related malnutrition in adults 2021 · Cochrane Headline outcomes only
  RR 0.36 [0.04, 3.24]
  1 study · 50 participants
  Low

Glucocorticoid with cyclophosphamide plus usual care vs placebo or usual care

The review found no eligible studies for this question.

• Glucocorticoid with cyclophosphamide for oral paraquat poisoning 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found