Cochrane · systematic review · CD008084
Glucocorticoid with cyclophosphamide for oral paraquat poisoning
Li, LR, Chaudhary, B, You, C, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
InjuriesAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
4
current version
GRADE rated
3
No studies
1
Included studies
NR
No studies 1 · 25%Ungraded 0 · 0%Very low 1 · 25%Low 2 · 50%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Glucocorticoid with cyclophosphamide plus usual care compared to usual care (with or without placebo) for oral paraquat poisoning
Population: people with moderate to severe oral paraquat poisoning
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality at 30 days following the ingestion of paraquat Glucocorticoid with cyclophosphamide plus usual care vs usual care (with or without placebo) | no estimate extracted | NR | No studies |
All‐cause mortality at final Glucocorticoid with cyclophosphamide plus usual care vs usual care (with or without placebo) | RR 0.82 | 2 studies · 322 participants | Low Downgraded: imprecision, inconsistency |
All‐cause mortality at final Glucocorticoid with cyclophosphamide plus usual care vs usual care (with or without placebo) | RR 0.98 [0.85, 1.13] | 1 study · 293 participants | Low Downgraded: imprecision, indirectness |
New infection within 1 week after initiation of treatment Assessed through clinical diagnosis Glucocorticoid with cyclophosphamide plus usual care vs usual care (with or without placebo) | no estimate extracted | 0 studies · 0 participants | Very low Downgraded: imprecision, indirectness |