Findings

What do systematic reviews say?

4,587 questions · 5,761 findings · 495 reviews

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No studies found 1,011 · 17.5%GRADE not reported 1,797 · 31.2%Very low 1,100 · 19.1%Low 1,052 · 18.3%Moderate 649 · 11.3%High 152 · 2.6%

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Intramuscular corticosteroids vs oral corticosteroid

Persistence of symptoms · patients with acute asthma

Intramuscular corticosteroids showed no clear difference in symptom persistence compared with oral corticosteroids (low certainty).

1 finding from 1 review

Intramuscular versus oral corticosteroids to reduce relapses following discharge from the emergency department for… 2018 · Cochrane Headline outcomes only
RR 0.41 [0.14, 1.2]
3 studies · 80 participants
Low

Intramuscular corticosteroids vs oral corticosteroid

24‐hour beta agonist use · patients with acute asthma

Intramuscular corticosteroids showed no clear difference in 24‐hour beta agonist use compared with oral corticosteroids (low certainty).

1 finding from 1 review

Intramuscular versus oral corticosteroids to reduce relapses following discharge from the emergency department for… 2018 · Cochrane Headline outcomes only
RR 0.54 [0.21, 1.37]
2 studies · 48 participants
Low

Low‐dose adjuvant radiotherapy vs standard‐dose adjuvant radiotherapy

Overall survival · patients with HPV‐positive oropharyngeal carcinoma who have received minimally invasive transoral surgery

The review found no eligible studies for this question.

1 finding from 1 review

De‐intensified adjuvant (chemo)radiotherapy versus standard adjuvant chemoradiotherapy post transoral minimally… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Low‐dose adjuvant radiotherapy vs standard‐dose adjuvant radiotherapy

Disease-free survival · patients with HPV‐positive oropharyngeal carcinoma who have received minimally invasive transoral surgery

The review found no eligible studies for this question.

1 finding from 1 review

De‐intensified adjuvant (chemo)radiotherapy versus standard adjuvant chemoradiotherapy post transoral minimally… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Low‐dose adjuvant radiotherapy vs standard‐dose adjuvant radiotherapy

Swallowing ability · patients with HPV‐positive oropharyngeal carcinoma who have received minimally invasive transoral surgery

The review found no eligible studies for this question.

1 finding from 1 review

De‐intensified adjuvant (chemo)radiotherapy versus standard adjuvant chemoradiotherapy post transoral minimally… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Low‐dose adjuvant radiotherapy vs standard‐dose adjuvant radiotherapy

Voice (Voice Handicap Index) · patients with HPV‐positive oropharyngeal carcinoma who have received minimally invasive transoral surgery

The review found no eligible studies for this question.

1 finding from 1 review

De‐intensified adjuvant (chemo)radiotherapy versus standard adjuvant chemoradiotherapy post transoral minimally… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Standard‐dose adjuvant radiotherapy alone vs adjuvant chemoradiotherapy

Overall survival · patients with HPV‐positive oropharyngeal carcinoma who have received minimally invasive transoral surgery

The review found no eligible studies for this question.

1 finding from 1 review

De‐intensified adjuvant (chemo)radiotherapy versus standard adjuvant chemoradiotherapy post transoral minimally… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Standard‐dose adjuvant radiotherapy alone vs adjuvant chemoradiotherapy

Disease-free survival · patients with HPV‐positive oropharyngeal carcinoma who have received minimally invasive transoral surgery

The review found no eligible studies for this question.

1 finding from 1 review

De‐intensified adjuvant (chemo)radiotherapy versus standard adjuvant chemoradiotherapy post transoral minimally… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Standard‐dose adjuvant radiotherapy alone vs adjuvant chemoradiotherapy

Swallowing ability · patients with HPV‐positive oropharyngeal carcinoma who have received minimally invasive transoral surgery

The review found no eligible studies for this question.

1 finding from 1 review

De‐intensified adjuvant (chemo)radiotherapy versus standard adjuvant chemoradiotherapy post transoral minimally… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Standard‐dose adjuvant radiotherapy alone vs adjuvant chemoradiotherapy

Voice (Voice Handicap Index) · patients with HPV‐positive oropharyngeal carcinoma who have received minimally invasive transoral surgery

The review found no eligible studies for this question.

1 finding from 1 review

De‐intensified adjuvant (chemo)radiotherapy versus standard adjuvant chemoradiotherapy post transoral minimally… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

SDAC vs no intervention

Incidence of mortality · first aid in patients with acute oral poisoning (paracetamol or not specified)

The review found no eligible studies for this question.

1 finding from 1 review

First aid interventions by laypeople for acute oral poisoning 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

SDAC + hospital intervention vs hospital intervention

Incidence and severity of symptoms of poisoning: incidence of need for intubation · first aid in patients with acute oral poisoning (not specified, tricyclic antidepressants, combinations of different drugs or yellow…

1 finding from 1 review

First aid interventions by laypeople for acute oral poisoning 2018 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 3562 participants
Very low

SDAC + hospital intervention vs hospital intervention

Duration of intubation · first aid in patients with acute oral poisoning (not specified, tricyclic antidepressants, combinations of different drugs or yellow…

1 finding from 1 review

First aid interventions by laypeople for acute oral poisoning 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 2 participants
Low

SDAC + hospital intervention vs hospital intervention

Drug absorption: cardenolide: AUC (µg/L × h) · first aid in patients with acute oral poisoning (not specified, tricyclic antidepressants, combinations of different drugs or yellow…

1 finding from 1 review

First aid interventions by laypeople for acute oral poisoning 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 68 participants
Very low

SDAC + hospital intervention vs hospital intervention

Hospitalization · first aid in patients with acute oral poisoning (not specified, tricyclic antidepressants, combinations of different drugs or yellow…

It is very uncertain whether SDAC + hospital intervention changes incidence of hospitalization compared with hospital intervention alone (very low certainty).

1 finding from 1 review

First aid interventions by laypeople for acute oral poisoning 2018 · Cochrane Headline outcomes only
RR 1.57 [1.22, 2.02]
1 study · 1479 participants
Very low

SDAC + hospital intervention vs hospital intervention

Incidence of admissions to the ICU · first aid in patients with acute oral poisoning (not specified, tricyclic antidepressants, combinations of different drugs or yellow…

It is very uncertain whether SDAC + hospital intervention changes incidence of ICU admission compared with hospital intervention alone (very low certainty).

1 finding from 1 review

First aid interventions by laypeople for acute oral poisoning 2018 · Cochrane Headline outcomes only
RR 2.33 [1.42, 3.82]
1 study · 1479 participants
Very low

MDAC + hospital intervention vs SDAC + hospital intervention

Incidence of mortality · first aid in patients with acute oral poisoning (carbamazepine, yellow oleander, or combinations of different drugs)

It is very uncertain whether MDAC + hospital intervention changes incidence of mortality compared with SDAC + hospital intervention (very low certainty).

1 finding from 1 review

First aid interventions by laypeople for acute oral poisoning 2018 · Cochrane Headline outcomes only
RR 0.59 [0.21, 1.63]
2 studies · 3476 participants
Very low

MDAC + hospital intervention vs SDAC + hospital intervention

Incidence of adverse events · first aid in patients with acute oral poisoning (carbamazepine, yellow oleander, or combinations of different drugs)

MDAC + hospital intervention may leads to higher incidence of adverse events compared with SDAC + hospital intervention (low certainty).

1 finding from 1 review

First aid interventions by laypeople for acute oral poisoning 2018 · Cochrane Headline outcomes only
Peto OR 3.55 [1.85, 6.79]
2 studies · 3476 participants
Low

MDAC + hospital intervention vs SDAC + hospital intervention

Incidence and severity of symptoms of poisoning: incidence of need for intubation · first aid in patients with acute oral poisoning (carbamazepine, yellow oleander, or combinations of different drugs)

MDAC + hospital intervention showed no clear difference in incidence and severity of symptoms of poisoning: incidence of need… compared with SDAC + hospital intervention (low certainty).

1 finding from 1 review

First aid interventions by laypeople for acute oral poisoning 2018 · Cochrane Headline outcomes only
RR 1.01 [0.75, 1.38]
2 studies · 3097 participants
Low

MDAC + hospital intervention vs SDAC + hospital intervention

Duration of intubation · first aid in patients with acute oral poisoning (carbamazepine, yellow oleander, or combinations of different drugs)

1 finding from 1 review

First aid interventions by laypeople for acute oral poisoning 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 2 participants
Very low