Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,808 questions · 8,953 findings · 827 reviews · Headline outcomes only

No studies found 1,891 · 21.1%GRADE not reported 380 · 4.2%Very low 2,100 · 23.5%Low 2,449 · 27.4%Moderate 1,684 · 18.8%High 449 · 5%

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ALK inhibitor vs any cytotoxic chemotherapy

Progression‐free survival · advanced anaplastic lymphoma kinase (ALK)‐rearranged non‐small cell lung cancer

ALK inhibitor leads to lower progression‐free survival: all participants compared with any cytotoxic chemotherapy (high certainty).

1 finding from 1 review

ALK inhibitor vs any cytotoxic chemotherapy

Progression‐free survival in people with central nervous system disease · advanced anaplastic lymphoma kinase (ALK)‐rearranged non‐small cell lung cancer

ALK inhibitor leads to lower progression‐free survival in people with central nervous system… compared with any cytotoxic chemotherapy (high certainty).

1 finding from 1 review

ALK inhibitor vs any cytotoxic chemotherapy

Grade 5 adverse events (excluding progressive disease) · advanced anaplastic lymphoma kinase (ALK)‐rearranged non‐small cell lung cancer

ALK inhibitor showed no clear difference in grade 5 adverse events (excluding progressive disease) compared with any cytotoxic chemotherapy (low certainty).

1 finding from 1 review

ALK inhibitor vs any cytotoxic chemotherapy

Health‐related quality of life: time to deterioration in composite endpoint (cough, dyspnoea, and chest pain) · advanced anaplastic lymphoma kinase (ALK)‐rearranged non‐small cell lung cancer

ALK inhibitor leads to lower health‐related quality of life: time to deterioration in composite… compared with any cytotoxic chemotherapy (high certainty).

1 finding from 1 review

Summary of findings: Single vs combination intravenous anti‐pseudomonal antibiotic therapy

Change in FEV1 % predicted at end of antibiotic course: absolute post‐treatment values · adults and children with cystic fibrosis

Summary of findings: single showed no clear difference in change in FEV1 % predicted at end of antibiotic course: absolute… compared with combination intravenous anti‐pseudomonal antibiotic therapy (low certainty).

1 finding from 1 review

Summary of findings: Single vs combination intravenous anti‐pseudomonal antibiotic therapy

Time to next course of antibiotics  · adults and children with cystic fibrosis

The review found no eligible studies for this question.

2 findings from 1 review

Summary of findings: Single vs combination intravenous anti‐pseudomonal antibiotic therapy

Adverse events during treatment · adults and children with cystic fibrosis

The review found no eligible studies for this question.

2 findings from 1 review

Summary of findings: Single vs combination intravenous anti‐pseudomonal antibiotic therapy

Change in sputum P aeruginosa density at end of treatment (cfu/g) · adults and children with cystic fibrosis

Summary of findings: single showed no clear difference in change in sputum P aeruginosa density at end of treatment (cfu/g) compared with combination intravenous anti‐pseudomonal antibiotic therapy (moderate certainty).

2 findings from 1 review

Summary of findings: Single vs combination intravenous anti‐pseudomonal antibiotic therapy

Need for extra treatment · adults and children with cystic fibrosis

The review found no eligible studies for this question.

2 findings from 1 review

Intervention not reported

Overall survival: 1‐year survival rate  · stages I to III NSCLC patients treated with surgery or radiotherapy with curative intent

The intervention showed no clear difference in overall survival: 1‐year survival rate  (low certainty).

1 finding from 1 review

Intervention not reported

Overall survival: 2‐year survival rate · stages I to III NSCLC patients treated with surgery or radiotherapy with curative intent

The intervention showed no clear difference in overall survival: 2‐year survival rate (moderate certainty).

1 finding from 1 review