What do systematic reviews say?

Selective carious tissue removal (selective excavation, SE) vs Stepwise carious tissue removal (SW)

• Interventions for treating cavitated or dentine carious lesions 2021 · Cochrane All outcomes

  Permanent and primary dentition
  Cost-effectiveness reported narratively: SE found more cost-effective than SW in permanent (Labib 2019) and primary teeth (Elhennawy 2021); not GRADE-rated.
  2 studies
  GRADE not reported

Intervention not reported

Caries prevalence in Sudan was 57.8% (95% CI 36.0 to 79.7); certainty not graded.

• Prevalence of Dental Caries and Associated Factors in East Africa, 2000-2020: Systematic Review and Meta-Analysis. 2021 All outcomes

  Community- and school-based populations, East Africa · Sudan
  Prevalence 0.578 [0.360, 0.797]
  Studies not reported
  GRADE not reported

Any of the interventions (CR, SE, SW, sealing with sealant materials, Hall Technique, or NRCC) vs Each other, placebo, or no treatment

The review found no eligible studies for this question.

• Interventions for treating cavitated or dentine carious lesions 2021 · Cochrane All outcomes
  We found no studies reporting subjective evaluation of the treatments by participants.
  0 studies
  No studies found

Sealing using sealant materials vs Selective carious tissue removal (selective excavation, SE)

• Interventions for treating cavitated or dentine carious lesions 2021 · Cochrane All outcomes

  Cavitated lesions, primary dentition
  Lesion progression reported narratively: Dias 2018 1/27 sealed vs 1/21 SE at 24 months; Hesse 2014 0/17 sealed vs 0/17 SE at 18 months; not pooled and not GRADE-rated.
  2 studies
  GRADE not reported

Selective carious tissue removal (selective excavation, SE) vs Stepwise carious tissue removal (SW)

Selective carious tissue removal (selective excavation, SE) probably leads to higher failure of therapy compared with stepwise carious tissue removal (SW) (moderate certainty).

• Interventions for treating cavitated or dentine carious lesions 2021 · Cochrane All outcomes

  12-60 months · Deep lesions, permanent dentition
  OR 2.25 [1.33, 3.82]
  3 studies · 371 participants
  Moderate
• Interventions for treating cavitated or dentine carious lesions 2021 · Cochrane All outcomes

  12-24 months · Deep lesions, primary dentition
  OR 2.05 [0.49, 8.62]
  2 studies · 126 participants
  Very low

Intervention not reported

Caries prevalence was highest in the Tigray region at 46.59% (95% CI 24.64 to 68.54); certainty not graded.

• Dental caries and associated factors in Ethiopia: systematic review and meta-analysis. 2021 All outcomes

  Community-, school-, and hospital/clinic-based populations across regions of Ethiopia · Tigray
  Prevalence 0.4659 [0.2464, 0.6854]
  2 studies
  GRADE not reported

Non-selective carious tissue removal and conventional restoration (CR) vs Hall Technique (sealing with a preformed metal crown)

• Interventions for treating cavitated or dentine carious lesions 2021 · Cochrane All outcomes

  Primary dentition
  Cost-effectiveness reported narratively: HT found more cost-effective than CR in primary teeth (Innes 2011; Santamaria 2018); not GRADE-rated.
  2 studies
  GRADE not reported

Intervention not reported

The pooled prevalence of dental caries in Ethiopia (2000-2020) was 40.98% (95% CI 31.62 to 50.34), with very high heterogeneity (I2=98.6%); certainty not graded.

• Dental caries and associated factors in Ethiopia: systematic review and meta-analysis. 2021 All outcomes

  Community-, school-, and hospital/clinic-based populations across regions of Ethiopia
  Prevalence 0.4098 [0.3162, 0.5034]
  13 studies · 6950 participants
  GRADE not reported

Non-selective carious tissue removal and conventional restoration (CR) vs Selective carious tissue removal (selective excavation, SE)

• Interventions for treating cavitated or dentine carious lesions 2021 · Cochrane All outcomes

  Cavitated but not deep lesions, primary dentition
  Lesion progression reported narratively: Ribeiro 1999 found 6/24 lesions progressed after 12 months; not pooled and not GRADE-rated.
  1 study
  GRADE not reported

Continuous infusion vs forced (or pulse) infusion of thrombolytic agents

• Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 304 participants
  Very low

Continuous infusion vs forced (or pulse) infusion of thrombolytic agents

• Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 164 participants
  Very low

Continuous infusion vs forced (or pulse) infusion of thrombolytic agents

• Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 304 participants
  Very low

Continuous infusion vs forced (or pulse) infusion of thrombolytic agents

• Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 304 participants
  Very low

Continuous infusion vs forced (or pulse) infusion of thrombolytic agents

• Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 304 participants
  Very low

Continuous infusion vs forced (or pulse) infusion of thrombolytic agents

• Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 304 participants
  Very low

Continuous infusion vs forced (or pulse) infusion of thrombolytic agents

• Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 304 participants
  Very low

Summary of Findings Table ‐ PBI?APBI vs WBRT

Summary of Findings Table ‐ PBI?APBI probably leads to higher local recurrence‐free survival ‐ total (LR‐FS) compared with WBRT (moderate certainty).

• Partial breast irradiation versus whole breast radiotherapy for early breast cancer 2021 · Cochrane Headline outcomes only
  HR 1.21 [1.03, 1.42]
  8 studies · 13168 participants
  Moderate

Summary of Findings Table ‐ PBI?APBI vs WBRT

Summary of Findings Table ‐ PBI?APBI probably leads to higher cosmesis, physician/nurse‐reported compared with WBRT (moderate certainty).

• Partial breast irradiation versus whole breast radiotherapy for early breast cancer 2021 · Cochrane Headline outcomes only
  OR 1.57 [1.31, 1.87]
  6 studies · 3652 participants
  Moderate

Summary of Findings Table ‐ PBI?APBI vs WBRT

Summary of Findings Table ‐ PBI?APBI showed no clear difference in overall survival compared with WBRT (high certainty).

• Partial breast irradiation versus whole breast radiotherapy for early breast cancer 2021 · Cochrane Headline outcomes only
  HR 0.99 [0.88, 1.12]
  8 studies · 13175 participants
  High

Summary of Findings Table ‐ PBI?APBI vs WBRT

Summary of Findings Table ‐ PBI?APBI probably leads to higher subcutaneous fibrosis (late RT toxicity) compared with WBRT (moderate certainty).

• Partial breast irradiation versus whole breast radiotherapy for early breast cancer 2021 · Cochrane Headline outcomes only
  OR 5.07 [3.81, 6.74]
  2 studies · 3011 participants
  Moderate