Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,413 questions · 2,602 findings · 93 reviews · Oral Health

No studies found 452 · 17.4%GRADE not reported 1,582 · 60.8%Very low 392 · 15.1%Low 122 · 4.7%Moderate 53 · 2%High 1 · 0%

Oral diclofenac sodium (NSAID) vs placebo

Daily pain (not improved) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral diclofenac sodium (NSAID) showed no clear difference in daily pain (not improved) compared with placebo; GRADE not reported.

1 finding from 1 review

Mechanical debridement plus topical minocycline vs Mechanical debridement plus chlorhexidine gel

Soreness in the gums · Adults with dental implants and peri-implant mucositis at baseline

Mechanical debridement plus topical minocycline showed no clear difference in soreness in the gums compared with mechanical debridement plus chlorhexidine gel; GRADE not reported.

1 finding from 1 review

Inlay/interposed bone graft (iliac or Bio-Oss block) + longer implants (vertical augmentation) vs Short implants (8 to 11 mm) without augmentation

Severe pain for > 1 week · Patients with atrophic (resorbed) mandibles needing implants

Inlay/interposed bone graft (iliac or Bio-Oss block) + longer… led to higher severe pain for > 1 week compared with short implants (8 to 11 mm) without augmentation; GRADE not reported.

1 finding from 1 review

Aciclovir (oral or intravenous) for treatment vs placebo

Time to complete healing · Patients being treated for cancer with established oral HSV infection (bone marrow transplant recipients / immunocompromised)
1 finding from 1 review

Two-stage sinus lift + buccal onlay iliac grafts WITH platelet-rich plasma (PRP) vs Same grafts WITHOUT PRP (split-mouth)

Implant/prosthesis failure and complications · Patients with resorbed maxillae (incl. atrophic sinuses) needing implants
1 finding from 1 review

Any denture cleansing method (mechanical or chemical) vs Another therapy, placebo, or no treatment

Costs · Adults (over 18) wearing complete dentures (CD) or removable partial dentures (RPD)

The review found no eligible studies for this question.

1 finding from 1 review
  • Interventions for cleaning dentures in adults 2009 · Cochrane All outcomes
    Noticeable absence of reports about costs of materials associated with denture cleansing methods; no included study assessed costs (Discussion; Implications for research).
    0 studies
    No studies found

Vertical distraction osteogenesis vs Autogenous onlay bone graft (mandibular ramus)

Augmentation procedure (partial) failure · Patients with vertically deficient posterior/anterior mandibular ridges needing implants

Vertical distraction osteogenesis showed no clear difference in augmentation procedure (partial) failure compared with autogenous onlay bone graft (mandibular ramus); GRADE not reported.

1 finding from 1 review

Primary surgical intervention (curettage, peripheral osteotomy, or resection) vs Primary non-surgical intervention (intralesional corticosteroids, subcutaneous calcitonin, interferon alpha, or imatinib)

Overall survival · Patients with a pathological diagnosis of central giant cell granuloma (CGCG) of the jaws

The review found no eligible studies for this question.

1 finding from 1 review

Inlay autogenous bone graft (iliac crest) vs Inlay bone substitute (Bio-Oss block)

Perimplant bone loss · Patients with atrophic posterior mandibles (5 to 7 mm above the mandibular canal) needing implants

Inlay autogenous bone graft (iliac crest) showed no clear difference in perimplant bone loss compared with inlay bone substitute (Bio-Oss block); GRADE not reported.

1 finding from 1 review

Inlay autogenous bone graft (iliac crest) vs Inlay bone substitute (Bio-Oss block)

Vertical bone gain · Patients with atrophic posterior mandibles (5 to 7 mm above the mandibular canal) needing implants

Inlay autogenous bone graft (iliac crest) showed no clear difference in vertical bone gain compared with inlay bone substitute (Bio-Oss block); GRADE not reported.

1 finding from 1 review

Calcitonin (salmon calcitonin nasal spray 200 IU/day) vs placebo

Increase in volume of more than 10% compared to the pretreatment measurement · Patients with histologically confirmed CGCG in one or both jaws and normal serum calcium and parathyroid hormone (PTH) levels

Calcitonin (salmon calcitonin nasal spray 200 IU/day) showed no clear difference in increase in volume of more than 10% compared to the pretreatment… compared with placebo; GRADE not reported.

1 finding from 1 review

Prophylactic aciclovir (oral or intravenous) vs placebo

Amount of analgesia · Patients being treated for cancer (predominantly haematological malignancies)

The review found no eligible studies for this question.

1 finding from 1 review

Aciclovir (oral or intravenous) for treatment vs placebo

Recurrence of lesions · Patients being treated for cancer with established oral HSV infection (bone marrow transplant recipients / immunocompromised)

The review found no eligible studies for this question.

1 finding from 1 review

Aciclovir (oral or intravenous) for treatment vs placebo

Duration of viral shedding · Patients being treated for cancer with established oral HSV infection (bone marrow transplant recipients / immunocompromised)
1 finding from 1 review

Primary surgical intervention (curettage, peripheral osteotomy, or resection) vs Primary non-surgical intervention (intralesional corticosteroids, subcutaneous calcitonin, interferon alpha, or imatinib)

Disease-free survival · Patients with a pathological diagnosis of central giant cell granuloma (CGCG) of the jaws

The review found no eligible studies for this question.

1 finding from 1 review

Primary surgical intervention (curettage, peripheral osteotomy, or resection) vs Primary non-surgical intervention (intralesional corticosteroids, subcutaneous calcitonin, interferon alpha, or imatinib)

Resectability · Patients with a pathological diagnosis of central giant cell granuloma (CGCG) of the jaws

The review found no eligible studies for this question.

1 finding from 1 review

Primary surgical intervention (curettage, peripheral osteotomy, or resection) vs Primary non-surgical intervention (intralesional corticosteroids, subcutaneous calcitonin, interferon alpha, or imatinib)

Quality of life · Patients with a pathological diagnosis of central giant cell granuloma (CGCG) of the jaws

The review found no eligible studies for this question.

1 finding from 1 review

Prophylactic aciclovir (oral or intravenous) vs placebo

Patient quality of life · Patients being treated for cancer (predominantly haematological malignancies)

The review found no eligible studies for this question.

1 finding from 1 review

Aciclovir (oral or intravenous) for treatment vs placebo

Relief of pain · Patients being treated for cancer with established oral HSV infection (bone marrow transplant recipients / immunocompromised)
1 finding from 1 review

Any denture cleansing method (mechanical or chemical) vs Another method, sham/placebo, or no treatment

Outcome not reported · Adults (over 18) wearing complete dentures (CD) or removable partial dentures (RPD)
1 finding from 1 review
  • Interventions for cleaning dentures in adults 2009 · Cochrane All outcomes
    Although six RCTs were included in this review, the wide range of different interventions and outcome variables did not permit pooling of data in a meta-analysis. Isolated reports indicated that chemicals and brushing…
    6 studies
    GRADE not reported