Question · asked by 1 review
Aciclovir (oral or intravenous) for treatment vs placebo: Time to complete healing
- Population
- Patients being treated for cancer with established oral HSV infection (bone marrow transplant recipients / immunocompromised)
- Intervention
- Aciclovir (oral or intravenous) for treatment
- Comparison
- placebo
- Outcome
- Time to complete healing
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Aciclovir (oral or intravenous) for treatment vs Placebo Time to complete healing of lesions · Patients being treated for cancer with established oral HSV infection (bone marrow transplant recipients /… Interventions for the prevention and treatment of herpes simplex virus in patients being treated for cancer (2009) · Cochrane All outcomes | Two studies. Median time to total healing was shorter for patients receiving oral or intravenous aciclovir than placebo: median of 8 days versus 21 days, P = 0.01 (Shepp 1985); 13.9 days versus 20.7 days, P = 0.08… | 2 studies | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Interventions for the prevention and treatment of herpes simplex virus in patients being treated for cancer 2009 · Cochrane All outcomes | 2008-11 | Not listed | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.