What do systematic reviews say?

2,261 questions · 2,280 findings · 114 reviews · Cystic Fibrosis and Genetic Disorders

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No studies found 856 · 37.5%GRADE not reported 58 · 2.5%Very low 550 · 24.1%Low 502 · 22%Moderate 271 · 11.9%High 43 · 1.9%

Exercise vs no intervention

Range of Motion: flexion and extension · participants with haemophilia

1 finding from 1 review

Exercise for haemophilia 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 18 participants
Very low

Exercise vs no intervention

Strength: bicep strength · participants with haemophilia

1 finding from 1 review

Exercise for haemophilia 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 18 participants
Very low

Summary of findings ‐ Exercise A vs Exercise B

Adverse events · participants with haemophilia

The review found no eligible studies for this question.

1 finding from 1 review

Exercise for haemophilia 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ Exercise A vs Exercise B

Quality of life · participants with haemophilia

The review found no eligible studies for this question.

1 finding from 1 review

Exercise for haemophilia 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Hydroxyurea vs placebo or usual care

Frequency of blood transfusion · people with non‐transfusion‐dependent β‐thalassaemia

The review found no eligible studies for this question.

1 finding from 1 review

Hydroxyurea for reducing blood transfusion in non‐transfusion dependent beta thalassaemias 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Hydroxyurea vs placebo or usual care

All major adverse effects · people with non‐transfusion‐dependent β‐thalassaemia

The review found no eligible studies for this question.

1 finding from 1 review

Hydroxyurea for reducing blood transfusion in non‐transfusion dependent beta thalassaemias 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Hydroxyurea vs placebo or usual care

Quality of life · people with non‐transfusion‐dependent β‐thalassaemia

The review found no eligible studies for this question.

1 finding from 1 review

Hydroxyurea for reducing blood transfusion in non‐transfusion dependent beta thalassaemias 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Hydroxyurea vs placebo or usual care

Mean Hb F (g/dL) · people with non‐transfusion‐dependent β‐thalassaemia

The review found no eligible studies for this question.

1 finding from 1 review

Hydroxyurea for reducing blood transfusion in non‐transfusion dependent beta thalassaemias 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Frequency of transfusion · people with non‐transfusion dependent beta thalassaemia

The review found no eligible studies for this question.

1 finding from 1 review

Hydroxyurea for reducing blood transfusion in non‐transfusion dependent beta thalassaemias 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Major adverse effects ‐ Neutropenia · people with non‐transfusion dependent beta thalassaemia

It is very uncertain whether the intervention changes major adverse effects ‐ Neutropenia (very low certainty).

1 finding from 1 review

Hydroxyurea for reducing blood transfusion in non‐transfusion dependent beta thalassaemias 2016 · Cochrane Headline outcomes only
RR 9.93 [1.34, 73.67]
1 study · 61 participants
Very low

Intervention not reported

Major adverse effects ‐ Thrombocytopenia · people with non‐transfusion dependent beta thalassaemia

It is very uncertain whether the intervention changes major adverse effects ‐ Thrombocytopenia (very low certainty).

1 finding from 1 review

Hydroxyurea for reducing blood transfusion in non‐transfusion dependent beta thalassaemias 2016 · Cochrane Headline outcomes only
RR 3.68 [1.12, 12.07]
1 study · 61 participants
Very low

Intervention not reported

Quality of life · people with non‐transfusion dependent beta thalassaemia

The review found no eligible studies for this question.

1 finding from 1 review

Hydroxyurea for reducing blood transfusion in non‐transfusion dependent beta thalassaemias 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Mean Hb F at 24 weeks (g/dL) · people with non‐transfusion dependent beta thalassaemia

1 finding from 1 review

Hydroxyurea for reducing blood transfusion in non‐transfusion dependent beta thalassaemias 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 61 participants
Low

Oral protein calorie supplements vs no intervention, placebo or additional nutritional advice compared to placebo

Change in weight (kg) · children with chronic disease

1 finding from 1 review

Oral protein calorie supplementation for children with chronic disease 2015 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 125 participants
Moderate

Oral protein calorie supplements vs no intervention, placebo or additional nutritional advice compared to placebo

Change in weight z score · children with chronic disease

1 finding from 1 review

Oral protein calorie supplementation for children with chronic disease 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 109 participants
High

Oral protein calorie supplements vs no intervention, placebo or additional nutritional advice compared to placebo

Change in height · children with chronic disease

1 finding from 1 review

Oral protein calorie supplementation for children with chronic disease 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 109 participants
High

Oral protein calorie supplements vs no intervention, placebo or additional nutritional advice compared to placebo

Change in BMI · children with chronic disease

1 finding from 1 review

Oral protein calorie supplementation for children with chronic disease 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 109 participants
High

Oral protein calorie supplements vs no intervention, placebo or additional nutritional advice compared to placebo

Change in total calories (Kcal/day): at 12 months · children with chronic disease

1 finding from 1 review

Oral protein calorie supplementation for children with chronic disease 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 53 participants
High

Oral protein calorie supplements vs no intervention, placebo or additional nutritional advice compared to placebo

Change in total protein intake (g/day) at 3 months · children with chronic disease

1 finding from 1 review

Oral protein calorie supplementation for children with chronic disease 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 53 participants
High

Oral protein calorie supplements vs no intervention, placebo or additional nutritional advice compared to placebo

FEV1 · children with chronic disease

1 finding from 1 review

Oral protein calorie supplementation for children with chronic disease 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 70 participants
High