Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,262 questions · 2,405 findings · 248 reviews · Headline outcomes only

No studies found 507 · 21.1%GRADE not reported 93 · 3.9%Very low 657 · 27.3%Low 708 · 29.4%Moderate 387 · 16.1%High 53 · 2.2%

SMP vs usual care

Quality of life measured on multiple scales (0 to 100; higher score = better quality of life) Postintervention: first assessment after end of treatment; no later than 3 months · patients with osteoarthritis
1 finding from 1 review

Daily sedation interruption vs usual care or protocolized sedation strategies that do not include daily sedation interruption

Duration of mechanical ventilation · Critically ill adults receiving mechanical ventilation in ICU

Daily sedation interruption showed no clear difference in total duration of mechanical ventilation (days) compared with usual care or protocolized sedation strategies that do not include… (moderate certainty).

1 finding from 1 review

Daily sedation interruption vs usual care or protocolized sedation strategies that do not include daily sedation interruption

Duration of ICU stay · Critically ill adults receiving mechanical ventilation in ICU

Daily sedation interruption showed no clear difference in ICU length of stay (days) compared with usual care or protocolized sedation strategies that do not include… (moderate certainty).

1 finding from 1 review

Daily sedation interruption vs usual care or protocolized sedation strategies that do not include daily sedation interruption

Length of hospital stay · Critically ill adults receiving mechanical ventilation in ICU

Daily sedation interruption showed no clear difference in hospital length of stay (days) compared with usual care or protocolized sedation strategies that do not include… (moderate certainty).

1 finding from 1 review

Daily sedation interruption vs usual care or protocolized sedation strategies that do not include daily sedation interruption

Tracheostomy · Critically ill adults receiving mechanical ventilation in ICU

Daily sedation interruption probably leads to lower tracheostomy compared with usual care or protocolized sedation strategies that do not include… (moderate certainty).

1 finding from 1 review

Daily sedation interruption vs usual care or protocolized sedation strategies that do not include daily sedation interruption

Accidental removal of ETT · Critically ill adults receiving mechanical ventilation in ICU

Daily sedation interruption showed no clear difference in accidental removal of ETT compared with usual care or protocolized sedation strategies that do not include… (moderate certainty).

1 finding from 1 review

Daily sedation interruption vs usual care or protocolized sedation strategies that do not include daily sedation interruption

ICU mortality · Critically ill adults receiving mechanical ventilation in ICU

Daily sedation interruption showed no clear difference in ICU mortality compared with usual care or protocolized sedation strategies that do not include… (moderate certainty).

1 finding from 1 review

Psychological therapy vs Waitlist/Usual Care

Secondary outcome: acceptability of treatment · people with somatoform disorders and medically unexplained physical symptoms

Psychological therapy probably leads to lower acceptability 1 ‐ proportion of participants withdrawing during… compared with usual care or waiting list (moderate certainty).

1 finding from 1 review

Psychological therapy vs Waitlist/Usual Care

Global Impressions scale change item (CGI‐I or similar): no. of responders (acute phase) · people with somatoform disorders and medically unexplained physical symptoms

Psychological therapy may leads to higher treatment response at end of treatment CGI‐improvement/Global… compared with usual care or waiting list (low certainty).

1 finding from 1 review

Annual chest x‐ray screening vs usual care (no regular screening)

Mortality: lung cancer · Patients with lung cancer

Annual chest x‐ray screening showed no clear difference in lung cancer mortality at 6 years of compared with usual care (no regular screening) (high certainty).

2 findings from 1 review