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Evidence found and GRADE certainty

1,655 questions · 1,751 findings · 147 reviews · Pain, Palliative and Supportive Care

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No studies found 361 · 20.6%GRADE not reported 87 · 5%Very low 625 · 35.7%Low 367 · 21%Moderate 232 · 13.2%High 79 · 4.5%

Diclofenac vs paracetamol

Nausea and vomiting · children with acute postoperative pain

It is very uncertain whether diclofenac changes nausea, vomiting, or both during study period № of participants: 348… compared with paracetamol (very low certainty).

1 finding from 1 review

Diclofenac vs paracetamol

Any bleeding during study period № of participants: 100(2 RCTs)d · children with acute postoperative pain

It is very uncertain whether diclofenac changes any bleeding during study period № of participants: 332 (5 RCTs) compared with paracetamol (very low certainty).

1 finding from 1 review

Diclofenac vs paracetamol

Serious adverse events during the study period · children with acute postoperative pain

It is very uncertain whether diclofenac changes serious adverse events during study period № of participants: 60 (1… compared with paracetamol (very low certainty).

1 finding from 1 review

Diclofenac vs bupivacaine

Nausea and vomiting · children with acute postoperative pain

It is very uncertain whether diclofenac changes nausea, vomiting, or both during study period № of participants: 128… compared with bupivacaine (very low certainty).

1 finding from 1 review

Diclofenac vs bupivacaine

Any bleeding during study period № of participants: 100(2 RCTs)d · children with acute postoperative pain

It is very uncertain whether diclofenac changes any bleeding during study period № of participants: 38 (1 RCTs) compared with bupivacaine (very low certainty).

1 finding from 1 review

Diclofenac vs bupivacaine

Serious adverse events during the study period · children with acute postoperative pain

It is very uncertain whether diclofenac changes serious adverse events during the study period № of participants: 38… compared with bupivacaine (very low certainty).

1 finding from 1 review

Diclofenac vs placebo

Nausea and vomiting · children with acute postoperative pain

It is very uncertain whether diclofenac changes nausea, vomiting, or both during study period № of participants:… compared with placebo (very low certainty).

1 finding from 1 review

Diclofenac vs placebo

Any bleeding during study period № of participants: 100(2 RCTs)d · children with acute postoperative pain

It is very uncertain whether diclofenac changes any bleeding during study period № of participants: 100(2 RCTs)d compared with placebo (very low certainty).

1 finding from 1 review

CR oxycodone vs IR oxycodone

Pain intensity (mean across treatment or at end of treatment; length of treatment varied across trials; various pain intensity scales; SMD) · adults with cancer‐related pain

It is very uncertain whether CR oxycodone changes pain intensity (mean across treatment or at end of treatment; length… compared with IR oxycodone (very low certainty).

1 finding from 1 review

CR oxycodone vs CR morphine

Constipation · adults with cancer‐related pain

It is very uncertain whether CR oxycodone changes constipation ‐ only English language studies (Event rate during… compared with CR morphine (very low certainty).

2 findings from 1 review

CR oxycodone vs CR morphine

Drowsiness/somnolence (Event rate during treatment, length of treatment varied across trials) · adults with cancer‐related pain

CR oxycodone showed no clear difference in drowsiness/somnolence (Event rate during treatment, length of… compared with CR morphine (low certainty).

1 finding from 1 review