Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

749 questions · 769 findings · 63 reviews · Headline outcomes only

No studies found 202 · 26.3%GRADE not reported 31 · 4%Very low 172 · 22.4%Low 211 · 27.4%Moderate 106 · 13.8%High 47 · 6.1%

Prophylactic oxytocin injection (delivered by community health officer) vs control (no injection)

Early infant death (0‐3 days) [ · pregnant women giving birth in non‐facility settings

Prophylactic oxytocin injection (delivered by community health… showed no clear difference in early infant death (0‐3 days) [ compared with control (no injection) (low certainty).

1 finding from 1 review

Summary of findings table ‐ Starting short‐term prophylactic dose anticoagulation vs avoiding anticoagulation

Death · survivors of stroke due to intracerebral haemorrhage

It is very uncertain whether summary of findings table ‐ Starting short‐term prophylactic dose… changes death compared with avoiding anticoagulation (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Starting short‐term prophylactic dose anticoagulation vs avoiding anticoagulation

Venous thromboembolism · survivors of stroke due to intracerebral haemorrhage

It is very uncertain whether summary of findings table ‐ Starting short‐term prophylactic dose… changes venous thromboembolism compared with avoiding anticoagulation (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Starting short‐term prophylactic dose anticoagulation vs avoiding anticoagulation

Intracerebral haemorrhage (ICH) · survivors of stroke due to intracerebral haemorrhage

It is very uncertain whether summary of findings table ‐ Starting short‐term prophylactic dose… changes intracerebral haemorrhage (ICH) compared with avoiding anticoagulation (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Starting short‐term prophylactic dose anticoagulation vs avoiding anticoagulation

Functional status: mRS 0‐2 · survivors of stroke due to intracerebral haemorrhage

It is very uncertain whether summary of findings table ‐ Starting short‐term prophylactic dose… changes functional status: mRS 0‐2 compared with avoiding anticoagulation (very low certainty).

1 finding from 1 review

Removal of short‐term indwelling urethral catheters in adults: prophylactic use of alpha blocker vs no intervention

Number of participants requiring recatheterisation · adults with short‐term indwelling urethral catheters that need to be removed

It is very uncertain whether removal of short‐term indwelling urethral catheters in adults:… changes number of participants requiring recatheterisation compared with no drug or intervention (very low certainty).

1 finding from 1 review

Removal of short‐term indwelling urethral catheters in adults: prophylactic use of alpha blocker vs no intervention

Symptomatic catheter associated urinary tract infection · adults with short‐term indwelling urethral catheters that need to be removed

It is very uncertain whether removal of short‐term indwelling urethral catheters in adults:… changes symptomatic catheter associated urinary tract infection compared with no drug or intervention (very low certainty).

1 finding from 1 review

Removal of short‐term indwelling urethral catheters in adults: prophylactic use of alpha blocker vs no intervention

Condition‐specific QoL or generic QoL measure · adults with short‐term indwelling urethral catheters that need to be removed

The review found no eligible studies for this question.

1 finding from 1 review

Pre‐emptive antifungal therapy vs empirical antifungal therapy

Proportion of antifungal agent use (other than prophylactic use) · people with cancer who have febrile neutropenia

It is very uncertain whether pre‐emptive antifungal therapy changes proportion of antifungal agent use (other than prophylactic use) compared with empirical antifungal therapy (very low certainty).

1 finding from 1 review

Antibiotic 1 vs antibiotic 2

Microbial resistance to prophylactic drugs: nitrofurantoin (1) versus cotrimoxazole (2) · children with primarily normal renal tracts who have experienced at least one UTI

Antibiotic 1 probably leads to lower microbial resistance to prophylactic drugs: nitrofurantoin (1)… compared with antibiotic 2 (moderate certainty).

1 finding from 1 review

Antibiotics vs placebo or no treatment

Microbial resistance to prophylactic drug · children with previous UTI and most do not have a renal tract abnormality such as VUR

Antibiotic treatment showed no clear difference in microbial resistance to prophylactic drug compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

MSCs vs placebo or control

Death during study period · patients with a haematological condition who receive a haematopoietic stem cell transplant as treatment for their condition.

MSCs showed no clear difference in all‐cause mortality (prophylactic trials) (over duration of trial) compared with control/placebo (low certainty).

1 finding from 1 review

MSCs vs placebo or control

Relapse of malignant disease (prophylactic trials) (>12‐month · patients with a haematological condition who receive a haematopoietic stem cell transplant as treatment for their condition.

MSCs showed no clear difference in relapse of malignant disease (prophylactic trials) (>12‐month compared with control/placebo (low certainty).

1 finding from 1 review

MSCs vs placebo or control

Incidence of acute GvHD (prophylactic trials) · patients with a haematological condition who receive a haematopoietic stem cell transplant as treatment for their condition.

MSCs showed no clear difference in incidence of acute GvHD (prophylactic trials) compared with control/placebo (low certainty).

1 finding from 1 review

MSCs vs placebo or control

Incidence of chronic GvHD (prophylactic trials) · patients with a haematological condition who receive a haematopoietic stem cell transplant as treatment for their condition.

MSCs may leads to lower incidence of chronic GvHD (prophylactic trials) compared with control/placebo (low certainty).

1 finding from 1 review