Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

230 questions · 242 findings · 27 reviews · Bone, Joint and Muscle Trauma

No studies found 64 · 26.4%GRADE not reported 7 · 2.9%Very low 86 · 35.5%Low 54 · 22.3%Moderate 20 · 8.3%High 11 · 4.5%

Antioxidants vs placebo

Muscle soreness · mainly physically active individuals1 partaking in exercise2 designed to produce delayed onset muscle soreness

Summary of findings: antioxidants showed no clear difference in muscle soreness compared with placebo (low certainty).

5 findings from 1 review
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Summary of findings: whole‐body cryotherapy (WBC) vs control (no WBC or passive rest)

Muscle pain at rest · physically‐active adults partaking in exercise designed to produce delayed onset muscle soreness (most trial participants were male)

It is very uncertain whether summary of findings: whole‐body cryotherapy (WBC) changes muscle soreness: pain at rest (VAS) compared with control (no WBC or passive rest) (very low certainty).

4 findings from 1 review
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Summary of findings: whole‐body cryotherapy (WBC) vs control (no WBC or passive rest)

Adverse events · physically‐active adults partaking in exercise designed to produce delayed onset muscle soreness (most trial participants were male)

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin D plus calcium vs placebo or control

Hip Fracture · post‐menopausal women and older people at risk of osteoporotic fractures

Vitamin D [D2, D3 or 25(OH)D] plus calcium leads to lower persons sustaining new hip fracture (1 year estimate) compared with control or placebo (high certainty).

1 finding from 1 review

Vitamin D plus calcium vs placebo or control

New fractures · post‐menopausal women and older people at risk of osteoporotic fractures

Vitamin D [D2, D3 or 25(OH)D] plus calcium leads to lower persons sustaining any new fracture (1 year estimate) compared with control or placebo (high certainty).

1 finding from 1 review

Vitamin D plus calcium vs placebo or control

Persons with hypercalcaemia ‐ Vitamin D (D2, D3 or 25(OH)D) plus calcium (1 year estimate) · post‐menopausal women and older people at risk of osteoporotic fractures

Vitamin D [D2, D3 or 25(OH)D] plus calcium showed no clear difference in persons with hypercalcaemia ‐ Vitamin D (D2, D3 or 25(OH)D) plus… compared with control or placebo (low certainty).

1 finding from 1 review

Vitamin D plus calcium vs placebo or control

Persons with renal disease (calculi or insufficiency) ‐ Vitamin D (D2, D3 or 25(OH)D) plus calcium (1 year estimate) · post‐menopausal women and older people at risk of osteoporotic fractures

Vitamin D [D2, D3 or 25(OH)D] plus calcium leads to higher persons with renal disease (calculi or insufficiency) ‐ Vitamin D… compared with control or placebo (high certainty).

1 finding from 1 review

Vitamin D plus calcium vs placebo or control

Deaths ‐ Vitamin D (D2, D3, 25(OH)D) plus calcium (1 year estimate) · post‐menopausal women and older people at risk of osteoporotic fractures

Vitamin D [D2, D3 or 25(OH)D] plus calcium showed no clear difference in deaths ‐ Vitamin D (D2, D3, 25(OH)D) plus calcium (1 year estimate) compared with control or placebo (high certainty).

1 finding from 1 review

Intervention not reported

Hip fractures at 1 year older people living in the community · older people

The intervention showed no clear difference in hip fractures at 1 year older people living in the community (moderate certainty).

1 finding from 1 review

Intervention not reported

Hip fractures at 1 year older people living in institutions · older people

The intervention showed no clear difference in hip fractures at 1 year older people living in institutions (moderate certainty).

1 finding from 1 review

Intervention not reported

Pelvic fractures at 1 year · older people

The intervention showed no clear difference in pelvic fractures at 1 year (low certainty).

1 finding from 1 review