Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

511 questions · 561 findings · 70 reviews · Gynaecology and Fertility

No studies found 91 · 16.2%GRADE not reported 5 · 0.9%Very low 140 · 25%Low 219 · 39%Moderate 98 · 17.5%High 8 · 1.4%

Thyroxine vs placebo or no treatment

Live birth rate – euthyroid women with anti‐TPO antibodies · subfertile women with euthyroid autoimmune thyroid disease or subclinical hypothyroidism

Thyroxine showed no clear difference in live birth rate – euthyroid women with anti‐TPO antibodies compared with placebo or no treatment (low certainty).

1 finding from 1 review

Thyroxine vs placebo or no treatment

Adverse events including maternal pregnancy complications, foetal complications and adverse effects of thyroxine · subfertile women with euthyroid autoimmune thyroid disease or subclinical hypothyroidism

Thyroxine led to lower adverse events including maternal pregnancy complications, foetal… compared with placebo or no treatment; GRADE not reported.

1 finding from 1 review

Thyroxine vs placebo or no treatment

Miscarriage – anti‐TPO antibodies · subfertile women with euthyroid autoimmune thyroid disease or subclinical hypothyroidism

Thyroxine showed no clear difference in miscarriage – anti‐TPO antibodies compared with placebo or no treatment (low certainty).

1 finding from 1 review