Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,411 questions · 1,474 findings · 170 reviews

No studies found 336 · 22.8%GRADE not reported 97 · 6.6%Very low 419 · 28.4%Low 395 · 26.8%Moderate 188 · 12.8%High 39 · 2.6%

Acyclovir vs erythromycin

The proportion of participants with good or excellent rash improvement within 2 weeks, as rated by a medical practitioner · pityriasis rosea
1 finding from 1 review

Clarithromycin vs placebo

The proportion of participants with good or excellent rash improvement within 2 weeks, as rated by a medical practitioner · pityriasis rosea

Clarithromycin showed no clear difference in the proportion of participants with good or excellent rash… compared with placebo (moderate certainty).

1 finding from 1 review

Metformin vs diet and exercise or another antidiabetic drug

Thiazolidinediones Diagnostic criteria: 2 trials applied the WHO 1999 criteria (FPG ≥ 7.0 mmol/L and/or a 2‐hour glucose ≥ 11.1 mmol/L after a 75 g OGTT) (Jin 2009; Zeng 2013). No medical association recommended the cut‐off points applied in Maji ... · people at increased risk for developing type 2 diabetes

Summary of findings table for metformin showed no clear difference in thiazolidinediones Diagnostic criteria: 2 trials applied the WHO… compared with diet and exercise or another antidiabetic drug (low certainty).

1 finding from 1 review

Effects of school‐based asthma interventions vs usual care

Unplanned visit to hospital or GP due to asthma symptoms (unplanned medical visits) · children with asthma

Effects of school‐based asthma interventions probably leads to lower unplanned visit to hospital or GP due to asthma symptoms (unplanned… compared with usual care (moderate certainty).

1 finding from 1 review

Exercise vs control (e.g. usual activities)

Number of people who experience a fall that required medical attention · Older people living in the community (trials focusing on people recently discharged from hospital were not included)

Summary of findings: exercise (all types) may leads to lower number of people who experienced one or more falls that required… compared with control (e.g. usual activities) (low certainty).

1 finding from 1 review

Interventions for involving older patients with multi‐morbidity in decision‐making about their health care vs usual care

Resource use and cost Number of nurse consultations at 15 months after baseline (extracted from patients’ routine electronic medical records) · older patients with multi‐morbidity

Interventions for involving older patients with multi‐morbidity in… probably leads to higher resource use and cost Number of nurse consultations at 15 months… compared with usual care (moderate certainty).

1 finding from 1 review

Antibiotics vs placebo

Children with progression of the disease resulting in additional medical therapy (complications) (measured as proportion of participants) · prolonged wet cough in children

Antibiotics probably leads to lower children with progression of the disease resulting in additional… compared with placebo (moderate certainty).

1 finding from 1 review

Isopropyl alcohol vs Normal saline

Nausea duration (nausea‐free at end of treatment) Measured by participant self‐report or medical or nursing observation · adults and children having any type of surgical procedure under general anaesthesia, regional anaesthesia or sedation, as hospital…

The review found no eligible studies for this question.

1 finding from 1 review