Findings

What do systematic reviews say?

1,822 questions · 1,891 findings · 321 reviews · Headline outcomes only

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No studies found 279 · 14.8%GRADE not reported 46 · 2.4%Very low 524 · 27.7%Low 571 · 30.2%Moderate 330 · 17.5%High 141 · 7.5%

Donepezil vs placebo

General health and function (Severity of Illness subscale of Clinical Global Impression Scale; lower = better) · children and adolescents with a diagnosis of autism

1 finding from 1 review

Acetylcholinesterase inhibitors for autistic spectrum disorders 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 34 participants
Very low

Galantamine plus risperidone vs placebo plus risperidone

Social communication (Lethargy/Social withdrawal subscale of the ABC‐C; 0 to 64; lower = better) · children and adolescents with a diagnosis of autism

1 finding from 1 review

Acetylcholinesterase inhibitors for autistic spectrum disorders 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 40 participants
Very low

Galantamine plus risperidone vs placebo plus risperidone

Stereotypical behaviours · children and adolescents with a diagnosis of autism

1 finding from 1 review

Acetylcholinesterase inhibitors for autistic spectrum disorders 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 40 participants
Very low

Galantamine plus risperidone vs placebo plus risperidone

Irritability · children and adolescents with a diagnosis of autism

1 finding from 1 review

Acetylcholinesterase inhibitors for autistic spectrum disorders 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 40 participants
Low

Galantamine plus risperidone vs placebo plus risperidone

Hyperactivity · children and adolescents with a diagnosis of autism

1 finding from 1 review

Acetylcholinesterase inhibitors for autistic spectrum disorders 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 40 participants
Low

Donepezil vs placebo

Overall autism features (total score of RLRS; raw score means; lower = better) · children and adolescents with a diagnosis of autism

1 finding from 1 review

Acetylcholinesterase inhibitors for autistic spectrum disorders 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 34 participants
Very low

Donepezil vs placebo

Social communication (Social Relationships subscale of RLRS; raw score means; lower = better) · children and adolescents with a diagnosis of autism

1 finding from 1 review

Acetylcholinesterase inhibitors for autistic spectrum disorders 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 34 participants
Very low

CBT vs TAU

AEs · chronic pain (excluding headache) in adults

It is very uncertain whether CBT changes adverse events (number of people with adverse events) (Lower events… compared with TAU (post‐treatment) (very low certainty).

1 finding from 1 review · compare the 2 reviews

Psychological therapies delivered remotely for the management of chronic pain (excluding headache) in adults 2023 · Cochrane Headline outcomes only
RR 6 [2.2, 16.4]
1 study · 140 participants
Very low

Summary of findings table ‐ Indicated prevention interventions vs control group

Diagnosis of mental disorders at study endpoint (RR < 1 denotes lower risk of mental diagnosis) · preventing mental disorders

It is very uncertain whether summary of findings table ‐ Indicated prevention interventions changes diagnosis of mental disorders at study endpoint (RR < 1 denotes… compared with control group (very low certainty).

2 findings from 1 review

Primary‐level and community worker interventions for the prevention of mental disorders and the promotion of… 2023 · Cochrane Headline outcomes only
RR 0.3 [0.06, 1.57]
3 studies · 843 participants
Very low
Primary‐level and community worker interventions for the prevention of mental disorders and the promotion of… 2023 · Cochrane Headline outcomes only
RR 0.77 [0.51, 1.17]
1 study · 220 participants
Very low

Summary of findings table ‐ Promotion/universal prevention interventions vs control group

Adverse events at study endpoint · preventing mental disorders

1 finding from 1 review

Primary‐level and community worker interventions for the prevention of mental disorders and the promotion of… 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 1 participants
Low

Summary of findings table ‐ Exercise plus usual pharmacological care vs placebo + standard care

Fatigue · systemic lupus erythematosus

1 finding from 1 review

Exercise as adjunctive therapy for systemic lupus erythematosus 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 17 participants
Low

Summary of findings table ‐ Exercise plus usual pharmacological care vs usual pharmacological care alone

Disease activity · systemic lupus erythematosus

1 finding from 1 review

Exercise as adjunctive therapy for systemic lupus erythematosus 2023 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 100 participants
Low

Summary of findings table ‐ Exercise plus usual pharmacological care vs usual pharmacological care alone

Pain (SF‐36 Bodily Pain domain, score 0‐100, lower scores indicate less pain) · systemic lupus erythematosus

1 finding from 1 review

Exercise as adjunctive therapy for systemic lupus erythematosus 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 31 participants
Very low

Summary of findings table ‐ Exercise plus usual pharmacological care vs another intervention (education, joint aids, or relaxation) plus usual pharmacological care

Fatigue · systemic lupus erythematosus

1 finding from 1 review

Exercise as adjunctive therapy for systemic lupus erythematosus 2023 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 119 participants
Low

Summary of findings table ‐ Exercise plus usual pharmacological care vs another intervention (education, joint aids, or relaxation) plus usual pharmacological care

Disease activity · systemic lupus erythematosus

1 finding from 1 review

Exercise as adjunctive therapy for systemic lupus erythematosus 2023 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 184 participants
Moderate

Summary of findings table ‐ Exercise plus usual pharmacological care vs another intervention (education, joint aids, or relaxation) plus usual pharmacological care

Participant‐reported pain intensity VAS (0‐10, lower score = less pain) · systemic lupus erythematosus

1 finding from 1 review

Exercise as adjunctive therapy for systemic lupus erythematosus 2023 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 121 participants
Low

Summary of findings table ‐ Exercise plus usual pharmacological care vs placebo + standard care

Pain (SF‐36 Bodily Pain domain, score 0‐100, lower scores indicate less pain) · systemic lupus erythematosus

1 finding from 1 review

Exercise as adjunctive therapy for systemic lupus erythematosus 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 17 participants
Low

Summary of findings table ‐ Exercise plus usual pharmacological care vs usual pharmacological care alone

Fatigue · systemic lupus erythematosus

1 finding from 1 review

Exercise as adjunctive therapy for systemic lupus erythematosus 2023 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 104 participants
Low

Intervention not reported

Mean postoperative BCVA (lower is better) · people with large macular hole

1 finding from 1 review

Pars plana vitrectomy with internal limiting membrane flap versus pars plana vitrectomy with conventional internal… 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Autoinflation vs no treatment

Disease‐specific quality of life · children aged 6 months to 12 years with otitis media with effusion (OME)

1 finding from 1 review

Autoinflation for otitis media with effusion (OME) in children 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low