Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

320 questions · 331 findings · 64 reviews · Headline outcomes only

No studies found 44 · 13.3%GRADE not reported 24 · 7.3%Very low 120 · 36.3%Low 90 · 27.2%Moderate 37 · 11.2%High 16 · 4.8%

Lithium as sole treatment vs placebo

Acceptability ‐ total dropouts · schizophrenia

Lithium as sole treatment showed no clear difference in acceptability of treatment leaving early due to any reason compared with placebo (low certainty).

1 finding from 1 review

Lithium vs antipsychotics

Acceptability ‐ total dropouts · schizophrenia

It is very uncertain whether lithium changes acceptability of treatment leaving early due to any reason compared with antipsychotics (very low certainty).

1 finding from 1 review

Aminophylline vs placebo

Early administration of aminophylline: survival to hospital admission · participants with bradyasystolic cardiac arrest in adults

Aminophylline showed no clear difference in early administration of aminophylline: survival to hospital admission compared with placebo (low certainty).

1 finding from 1 review

Aminophylline vs placebo

Return of spontaneous circulation · participants with bradyasystolic cardiac arrest in adults

Aminophylline showed no clear difference in early administration of aminophylline: return of spontaneous… compared with placebo (low certainty).

1 finding from 1 review

Summary of findings table 4: refining rehabilitation: three months of postoperative night splinting with hand therapy vs hand therapy alone

Total active extension at 3 months Major outcome group 3 (early objective measurement) Total active extension (TAE) of MCPJ, PIPJ and DIPJ; higher value indicates loss of extension and a worse outcome · 210 participants with Dupuytren's disease of the fingers in 2 studies (225 digits reported across all studies) (Collis 2013;…
1 finding from 1 review

Peripartum/postnatal prophylaxis: UFH vs no treatment

Symptomatic thromboembolic events ( · women with varicose veins before birth, having a caesarean (elective or emergency) or vaginal birth

It is very uncertain whether peripartum/postnatal prophylaxis: UFH changes symptomatic thromboembolic events ( compared with no treatment (very low certainty).

1 finding from 1 review

Peripartum/postnatal prophylaxis: UFH vs no treatment

Symptomatic PE · women with varicose veins before birth, having a caesarean (elective or emergency) or vaginal birth

It is very uncertain whether peripartum/postnatal prophylaxis: UFH changes symptomatic PE ( compared with no treatment (very low certainty).

1 finding from 1 review

Peripartum/postnatal prophylaxis: UFH vs no treatment

Symptomatic DVT · women with varicose veins before birth, having a caesarean (elective or emergency) or vaginal birth

It is very uncertain whether peripartum/postnatal prophylaxis: UFH changes symptomatic DVT ( compared with no treatment (very low certainty).

1 finding from 1 review

Non‐exclusive breastfeeding (artificial milk) vs exclusive breastfeeding

Any breastfeeding at hospital discharge · healthy breastfeeding full‐term infants

Non‐exclusive breastfeeding (artificial milk) showed no clear difference in any breastfeeding at discharge compared with exclusive breastfeeding (low certainty).

1 finding from 1 review

Non‐exclusive breastfeeding (artificial milk) vs exclusive breastfeeding

Infant morbidity ‐ allergy symptoms ‐ Infants with allergy symptoms at 18 months of age · healthy breastfeeding full‐term infants

It is very uncertain whether non‐exclusive breastfeeding (artificial milk) changes infant morbidity ‐ allergy symptoms ‐ Infants with allergy symptoms… compared with exclusive breastfeeding (very low certainty).

1 finding from 1 review