Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,888 questions · 2,009 findings · 352 reviews

No studies found 224 · 11.1%GRADE not reported 265 · 13.2%Very low 551 · 27.4%Low 540 · 26.9%Moderate 311 · 15.5%High 118 · 5.9%

Early treatment (two-phase) with headgear vs Early treatment (two-phase) with functional appliance

Final overjet · Children (7 to 11 years) and adolescents (12 to 16 years) with prominent upper front teeth (Class II malocclusion)

Early treatment (two-phase) with headgear showed no clear difference in final overjet compared with early treatment (two-phase) with functional appliance; GRADE not reported.

2 findings from 1 review

Planned early birth vs expectant management

Maternal mortality or morbidity · pregnant women with hypertensive disorders from 34 weeks' gestation to term

Planned early delivery leads to lower composite maternal mortality and morbidity compared with expectant management (high certainty).

1 finding from 1 review

Planned early birth vs expectant management

Perinatal mortality (stillbirth ‐ death of fetus prior to birth; neonatal death ‐ death within the first 28 days of birth; or infant death ‐ death after the first 28 days) · pregnant women with a term suspected compromised baby
1 finding from 1 review

Planned early birth vs expectant management

Major neonatal morbidity · pregnant women with a term suspected compromised baby

Planned early delivery showed no clear difference in major neonatal morbidity one or more of the following: hypoxic… compared with expectant management (low certainty).

1 finding from 1 review

Planned early birth vs expectant management

Neurodevelopmental disability · pregnant women with a term suspected compromised baby

Planned early delivery showed no clear difference in neurodevelopmental disability/impairment CBCL, Ages and Stages… compared with expectant management (low certainty).

1 finding from 1 review

Planned early birth vs expectant management

Significant maternal morbidity one or more of the following: significant postpartum haemorrhage requiring blood transfusion; maternal admission to intensive care unit; uterine rupture; hysterectomy · pregnant women with a term suspected compromised baby

Planned early delivery showed no clear difference in significant maternal morbidity one or more of the following:… compared with expectant management (low certainty).

1 finding from 1 review

Planned early birth vs expectant management

Admission to neonatal intensive care unit · pregnant women with a term suspected compromised baby

It is very uncertain whether planned early delivery changes admission to NICU compared with expectant management (very low certainty).

1 finding from 1 review

Early dressing removal vs delayed dressing removal

Postoperative superficial infections · people with surgical site infection

It is very uncertain whether early dressing removal changes superficial surgical site infection Superficial surgical site… compared with delayed dressing removal (very low certainty).

1 finding from 1 review

Early dressing removal vs delayed dressing removal

Superficial wound dehiscence · people with surgical site infection

It is very uncertain whether early dressing removal changes superficial wound dehiscence Superficial wound dehiscence reported… compared with delayed dressing removal (very low certainty).

1 finding from 1 review

Early dressing removal vs delayed dressing removal

Serious adverse events Patients experiencing serious adverse events within 30 days of surgery · people with surgical site infection

It is very uncertain whether early dressing removal changes serious adverse events Patients experiencing serious adverse events… compared with delayed dressing removal (very low certainty).

1 finding from 1 review