Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

677 questions · 719 findings · 133 reviews

No studies found 153 · 21.3%GRADE not reported 54 · 7.5%Very low 164 · 22.8%Low 199 · 27.7%Moderate 119 · 16.6%High 30 · 4.2%

Tacrolimus 0.1% vs Topical clobetasol propionate 0.05% ointment

Reduction in target/mean lesion size · People with erosive oral lichen planus

Topical tacrolimus 0.1% ointment showed no clear difference in reduction in target/mean lesion size compared with topical clobetasol propionate 0.05% ointment; GRADE not reported.

1 finding from 1 review

Fixed bonded acrylic splint expander vs no treatment

Molar expansion · Children and adults with a posterior crossbite, without a Class III skeletal relationship, cleft lip or palate (or both), or other…

Fixed bonded acrylic splint expander showed no clear difference in molar expansion (maxillary intermolar width) compared with no treatment; GRADE not reported.

1 finding from 1 review

Fixed bonded acrylic splint expander vs no treatment

Canine expansion · Children and adults with a posterior crossbite, without a Class III skeletal relationship, cleft lip or palate (or both), or other…

Fixed bonded acrylic splint expander showed no clear difference in canine expansion (maxillary intercanine width) compared with no treatment; GRADE not reported.

1 finding from 1 review

Carbopol (polyacrylic acid/acetate) spray vs Placebo spray

Dry mouth (xerostomia) · Adults seeking treatment for the symptom of dry mouth (xerostomia) due to any cause (e.g. medication, Sjogren's syndrome, radiotherapy,…
1 finding from 1 review

Carbopol (polyacrylic acid/acetate) spray vs Placebo spray

Patient preference · Adults seeking treatment for the symptom of dry mouth (xerostomia) due to any cause (e.g. medication, Sjogren's syndrome, radiotherapy,…
1 finding from 1 review
  • Patient preference for active sprays vs placebo nearly attained significance (Chi2 7.259, df=3; P = 0.064); 15/43 participants expressed no desire to continue any spray after the trial.
    1 study · 43 participants
    GRADE not reported

Regimens containing macrolides (azithromycin) vs regimens containing tetracycline (doxycycline)

Clinical cure according to criteria established by study authors Mild‐moderate PID · women with PID

It is very uncertain whether regimens containing macrolides (azithromycin) changes clinical cure according to criteria established by study authors… compared with regimens containing tetracycline (doxycycline) (very low certainty).

2 findings from 1 review

Regimens containing macrolides (azithromycin) vs regimens containing tetracycline (doxycycline)

Clinical cure according to criteria established by study authors Severe PID · women with PID

Regimens containing macrolides (azithromycin) showed no clear difference in clinical cure according to criteria established by study authors… compared with regimens containing tetracycline (doxycycline) (low certainty).

1 finding from 1 review

Regimens containing macrolides (azithromycin) vs regimens containing tetracycline (doxycycline)

Adverse events: any antibiotic‐related adverse event leading to discontinuation of therapy · women with PID

Regimens containing macrolides (azithromycin) showed no clear difference in adverse events: any antibiotic‐related adverse event leading to… compared with regimens containing tetracycline (doxycycline) (low certainty).

1 finding from 1 review