Findings

What do systematic reviews say?

2,908 questions · 3,101 findings · 509 reviews

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No studies found 571 · 18.4%GRADE not reported 358 · 11.5%Very low 723 · 23.3%Low 854 · 27.5%Moderate 489 · 15.8%High 106 · 3.4%

Intervention not reported

Systolic blood pressure · adults with primary hypertension

1 finding from 1 review

Blood pressure‐lowering efficacy of monotherapy with thiazide diuretics for primary hypertension 2014 · Cochrane Headline outcomes only
no estimate extracted
47 studies · 7733 participants
High

Intervention not reported

Diastolic blood pressure · adults with primary hypertension

1 finding from 1 review

Blood pressure‐lowering efficacy of monotherapy with thiazide diuretics for primary hypertension 2014 · Cochrane Headline outcomes only
no estimate extracted
51 studies · 8064 participants
High

Intervention not reported

Withdrawal due to adverse effects · adults with primary hypertension

1 finding from 1 review

Blood pressure‐lowering efficacy of monotherapy with thiazide diuretics for primary hypertension 2014 · Cochrane Headline outcomes only
no estimate extracted
20 studies · 3698 participants
Very low

Inhaled NO vs placebo or conventional therapy

Long‐term mortality · all infants and children with congenital heart disease having postoperative management of pulmonary hypertension

1 finding from 1 review

Inhaled nitric oxide for the postoperative management of pulmonary hypertension in infants and children with… 2014 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Inhaled NO vs placebo or conventional therapy

Mortality before hospital discharge · all infants and children with congenital heart disease having postoperative management of pulmonary hypertension

It is very uncertain whether inhaled nitric oxide changes mortality prior to discharge1 compared with placebo or conventional therapy (very low certainty).

1 finding from 1 review

Inhaled nitric oxide for the postoperative management of pulmonary hypertension in infants and children with… 2014 · Cochrane Headline outcomes only
OR 1.67 [0.38, 7.3]
2 studies · 162 participants
Very low

Inhaled NO vs placebo or conventional therapy

Difference in MPAP change score (SE) ‐ Conventional Management4 · all infants and children with congenital heart disease having postoperative management of pulmonary hypertension

1 finding from 1 review

Inhaled nitric oxide for the postoperative management of pulmonary hypertension in infants and children with… 2014 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 4 participants
Very low

Inhaled NO vs placebo or conventional therapy

Difference in MPAP change score (SE) ‐ Placebo4 · all infants and children with congenital heart disease having postoperative management of pulmonary hypertension

1 finding from 1 review

Inhaled nitric oxide for the postoperative management of pulmonary hypertension in infants and children with… 2014 · Cochrane Headline outcomes only
no estimate extracted
1 study · 2 participants
Very low

Inhaled NO vs placebo or conventional therapy

Difference in MAP change score (SE) ‐ Conventional Mangement4 · all infants and children with congenital heart disease having postoperative management of pulmonary hypertension

1 finding from 1 review

Inhaled nitric oxide for the postoperative management of pulmonary hypertension in infants and children with… 2014 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 4 participants
Very low

Inhaled NO vs placebo or conventional therapy

Difference in MAP change score (SE) ‐ Placebo4 · all infants and children with congenital heart disease having postoperative management of pulmonary hypertension

1 finding from 1 review

Inhaled nitric oxide for the postoperative management of pulmonary hypertension in infants and children with… 2014 · Cochrane Headline outcomes only
no estimate extracted
1 study · 2 participants
Very low

Intervention not reported

Decrease in systolic blood pressure · Adults with primary hypertension

1 finding from 1 review

Blood pressure lowering efficacy of partial agonist beta blocker monotherapy for primary hypertension 2014 · Cochrane Headline outcomes only
no estimate extracted
10 studies · 490 participants
Very low

Intervention not reported

Decrease in diastolic blood pressure · Adults with primary hypertension

1 finding from 1 review

Blood pressure lowering efficacy of partial agonist beta blocker monotherapy for primary hypertension 2014 · Cochrane Headline outcomes only
no estimate extracted
10 studies · 490 participants
Very low

Intervention not reported

Decrease in heart rate · Adults with primary hypertension

1 finding from 1 review

Blood pressure lowering efficacy of partial agonist beta blocker monotherapy for primary hypertension 2014 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 256 participants
Very low

Intervention not reported

Decrease in pulse pressure · Adults with primary hypertension

1 finding from 1 review

Blood pressure lowering efficacy of partial agonist beta blocker monotherapy for primary hypertension 2014 · Cochrane Headline outcomes only
no estimate extracted
10 studies · 490 participants
Very low

Intervention not reported

Withdrawal due to adverse effect · Adults with primary hypertension

1 finding from 1 review

Blood pressure lowering efficacy of partial agonist beta blocker monotherapy for primary hypertension 2014 · Cochrane Headline outcomes only
no estimate extracted
1 study · 117 participants
Very low

Nonselective beta‐blockers vs placebo

SBP (mmHg) · adults with primary hypertension

1 finding from 1 review

Blood pressure lowering efficacy of nonselective beta‐blockers for primary hypertension 2014 · Cochrane Headline outcomes only
no estimate extracted
16 studies · 948 participants
Low

Nonselective beta‐blockers vs placebo

Diastolic blood pressure · adults with primary hypertension

1 finding from 1 review

Blood pressure lowering efficacy of nonselective beta‐blockers for primary hypertension 2014 · Cochrane Headline outcomes only
no estimate extracted
16 studies · 948 participants
Low

Nonselective beta‐blockers vs placebo

Heart rate · adults with primary hypertension

1 finding from 1 review

Blood pressure lowering efficacy of nonselective beta‐blockers for primary hypertension 2014 · Cochrane Headline outcomes only
no estimate extracted
13 studies · 864 participants
Low

Nonselective beta‐blockers vs placebo

Pulse pressure · adults with primary hypertension

1 finding from 1 review

Blood pressure lowering efficacy of nonselective beta‐blockers for primary hypertension 2014 · Cochrane Headline outcomes only
no estimate extracted
16 studies · 948 participants
Very low

Nonselective beta‐blockers vs placebo

Withdrawals due to adverse events · adults with primary hypertension

1 finding from 1 review

Blood pressure lowering efficacy of nonselective beta‐blockers for primary hypertension 2014 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 729 participants
Low

Intervention not reported

High‐ versus low‐dose · children (from 1 to 18 years of age) with hypertension from primary or secondary causes

1 finding from 1 review

Pharmacological interventions for hypertension in children 2014 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 418 participants
Low