Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,227 questions · 2,562 findings · 156 reviews · All outcomes

No studies found 297 · 11.6%GRADE not reported 1,616 · 63.1%Very low 405 · 15.8%Low 144 · 5.6%Moderate 81 · 3.2%High 19 · 0.7%

Keratinocyte growth factor (KGF; palifermin or repifermin), intravenous vs placebo

Normalcy of diet (total parenteral nutrition) · Adults with cancer receiving treatment

Keratinocyte growth factor (KGF; palifermin or repifermin),… showed no clear difference in normalcy of diet (total parenteral nutrition) compared with placebo; GRADE not reported.

1 finding from 1 review

GM-CSF vs placebo or no treatment

Normalcy of diet (tube feeding) · Adults with cancer receiving treatment

Granulocyte-macrophage colony-stimulating factor (GM-CSF) showed no clear difference in normalcy of diet (tube feeding) compared with placebo or no treatment; GRADE not reported.

1 finding from 1 review

Erythropoietin mouthwash vs placebo

Number of days in hospital · Adults receiving bone marrow/stem cell transplantation after conditioning therapy for haematological cancers

Erythropoietin mouthwash showed no clear difference in number of days in hospital compared with placebo; GRADE not reported.

1 finding from 1 review

Dementia (any type or severity) vs Older people without dementia

Number of teeth · Older people (aged 60 years or older) with dementia

The number of teeth present was comparable between older people with and without dementia; no meta-analysis was performed (ungraded).

1 finding from 1 review

Keratinocyte growth factor (KGF; palifermin or repifermin), intravenous vs placebo

Number of days of treatment with opioid analgesics · Adults with cancer receiving treatment

Keratinocyte growth factor (KGF; palifermin or repifermin),… showed no clear difference in number of days of treatment with opioid analgesics compared with placebo; GRADE not reported.

1 finding from 1 review

Job-related or family-related stress and pessimistic attitude to life vs Lower stress and no pessimistic attitude

Periodontal disease and serum IL-1β IL-6 and cortisol · Patients with aggressive or chronic periodontitis at a university periodontology department

No correlation was reported between immunological markers cortisol and registered stress values; untreated aggressive periodontitis was accompanied by pessimistic attitude and elevated serum IL-6.

1 finding from 1 review

Perceived psychosocial stress vs No or lower perceived stress

GCF elastase activity and non-surgical periodontal treatment outcome (salivary cortisol, ICTP measured; no effect reported) · Adults with periodontitis needing non-surgical periodontal treatment

In one 6-month longitudinal study, patients under psychosocial stress had higher gingival crevicular fluid elastase and poorer outcomes after non-surgical periodontal therapy; not pooled (ungraded).

1 finding from 1 review

Educational intervention with information only (theoretical dental health education, no practical training) vs usual care

Denture-induced stomatitis · Residents of institutions for elderly people (nursing staff and residents took part in the education programme)
1 finding from 1 review

Depression and social isolation (psychosocial strain) vs No depression or lower psychosocial strain

Antibody titres to periodontal pathogens · Adults with periodontitis

In one case-control study, depression as a marker of social isolation was associated with elevated antibody titres to periodontal pathogens at baseline and 1-year follow-up; not pooled (ungraded).

1 finding from 1 review

Monitoring (any means of observation, supervision, keeping under review, measuring or testing at intervals) vs No monitoring

Quality of life: Chronic pain · People with serious mental illness (all included participants had schizophrenia); majority aged 18 to 65 years per NIMH 1987, or with…

The review found no eligible studies for this question.

1 finding from 1 review

Monitoring (any means of observation, supervision, keeping under review, measuring or testing at intervals) vs No monitoring

Service use: Emergency medical/dental treatment · People with serious mental illness (all included participants had schizophrenia); majority aged 18 to 65 years per NIMH 1987, or with…

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Serum inflammatory cytokines (IL-1b, IL-6) and cortisol in periodontitis
1 finding from 1 review

Educational intervention with information only (theoretical dental health education, no practical training) vs usual care

Denture plaque · Residents of institutions for elderly people (nursing staff and residents took part in the education programme)
1 finding from 1 review

Monitoring (any means of observation, supervision, keeping under review, measuring or testing at intervals) vs No monitoring

Adverse events: Clinically important specific adverse events · People with serious mental illness (all included participants had schizophrenia); majority aged 18 to 65 years per NIMH 1987, or with…

The review found no eligible studies for this question.

1 finding from 1 review

Monitoring (any means of observation, supervision, keeping under review, measuring or testing at intervals) vs No monitoring

Dental state: No clinically important change in plaque index · People with serious mental illness (all included participants had schizophrenia); majority aged 18 to 65 years per NIMH 1987, or with…

The review found no eligible studies for this question.

1 finding from 1 review

Dementia (any type or severity) vs Older people without dementia

Mean number of decayed teeth (mean DT) · Older people (aged 60 years or older) with dementia

Decayed-teeth values varied across studies and were not meta-analyzed.

1 finding from 1 review