Search review questions

Outcome NR · Children with decayed primary molar teeth

Pain, quality of life, patient satisfaction or costs · Children and adolescents below 18 years at study start (included studies: children from birth to 15 years), with…

Caries increment on permanent whole teeth (D(M)FT), prevented fraction · Children and adolescents aged 16 years or younger (permanent dentition) · Nearest to 3 years, No-treatment-controlled trials

Caries increment on primary (deciduous) whole teeth (d(m)ft), prevented fraction · Children with primary (deciduous) teeth (mostly preschool children aged under 6 years) · Nearest to 3 years

Presence of dental caries · Children with exclusively primary dentition (age ≤71 months)

Caries (lesion) progression (radiographic) · Dentate children and adults with non-cavitated proximal caries lesions extending into enamel or dentine (not pulp) in… · 12 to 36 months (radiographic follow-up), Resin infiltration

Disparities in caries across socioeconomic status (SES) · People of all ages in a previously fluoridated community (Maupome 2001: children with generally low caries experience)

Caries in primary teeth: dmft (3 years) · General population, irrespective of age or level of risk for dental caries · 3 years

Adverse events: gingival bleeding · Children with decayed primary molar teeth · Long term (12 months)

Pain · Children with decayed primary molar teeth · Short term (less than 12 months)

Adverse events: bone resorption · Children with decayed primary molar teeth · Six months and four years

Unacceptability of treatment (dropouts/exclusions during the trial) · Children and adolescents aged 16 years or younger · During trial, Placebo-controlled trials

Adverse effects · People of all ages in a previously fluoridated community (Maupome 2001: children with generally low caries experience)

Adverse events: gingival bleeding · Children with decayed primary molar teeth · Six months and four years

Caries in deciduous teeth (change in dmft) · People of all ages in a community setting; the included caries studies were all in children aged 3 to 16 years · Follow-up 3 to 12 years

Outcome NR · Children and adults · At least 1 year

Outcome NR · Children and adolescents below 18 years at study start (included studies: children from birth to 15 years), with…

Caries in permanent teeth (change in DMFS) · Children aged about 12 to 16 years (Hardwick 1982), community setting · Follow-up (single study, Hardwick 1982)

Elevated mutans streptococci levels (>=4 with caries screen; high vs low) · Children and adolescents below 18 years at study start (included studies: children from birth to 15 years), with… · 6 to 36 months, permanent dentition

Material deficiency (retention/adaptation loss; re-treatment) · Dentate children and adults with non-cavitated proximal caries lesions extending into enamel or dentine (not pulp) in… · 3 years

Caries increment in the primary teeth (d(m)fs/t) · Children and adolescents below 18 years at study start (included studies: children from birth to 15 years), with… · 24 months, primary dentition

Adverse events: gingival bleeding · Children with decayed primary molar teeth · Long term (12 months)

Change in proportion of caries-free children (deciduous teeth) · People of all ages in a community setting; the included caries studies were all in children aged 3 to 16 years · Follow-up 3 to 12 years

Caries in permanent teeth: DMFT (3 years) · General population, irrespective of age or level of risk for dental caries · 3 years

Adverse effects · Infants (primary teeth) · 12 months

Proportion of children not remaining caries-free · Children and adolescents aged 16 years or younger (permanent dentition) · Permanent dentition

Prostate cancer · Adults (general population)

Alzheimer’s disease · Participants in observational studies

Aggressive prostate cancer · Participants in observational studies

Fasting glucose · Adults with diabetes · Diabetes patients with normal glucose tolerance

Presence of clinical symptoms (pain, swelling, diagnosis of pulpitis, abscess formation) · Adults (16 years or over) with one or more defective resin composite restoration(s) in a molar or premolar tooth/teeth · Medium term (less than 5 years) or long term (5 years and above)

Type 2 diabetes · Adults (general population)

Risk of hypercalcaemia · Adults with chronic kidney disease requiring dialysis

Bone mineral density in femoral neck · Older or community-dwelling adults

Bone mineral density in lumbar spine · Older or community-dwelling adults

Sporadic colorectal adenoma recurrence · Adults (general population)

Ischaemic heart disease · Adults (general population)

Fractures: non-vertebral · Older or community-dwelling adults

Small for gestational age · Pregnant women and their offspring

Prostate cancer · Participants in observational studies

Breast cancer · Adults (general population) · Premenopausal

All cause mortality · Patients with chronic kidney disease

Metabolic syndrome (prevalent) · Adults (general population)

Performance measures: muscle strength · Older or community-dwelling adults

Cognition · Adults (general population)

Pre-eclampsia · Pregnant women and their offspring

Fractures: non-vertebral, non-hip · Older or community-dwelling adults

Head circumference · Pregnant women and their offspring

Diastolic blood pressure · Adults (general population)

Mean gestational age at delivery · Pregnant women