Dental caries · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)
rs1126478 showed no significant association with dental caries under a co-dominant model (OR 0.97, 95% CI 0.72 to 1.32; ungraded).
1 finding from 1 review
Intervention not reported
Marginal integrity success rate
1 finding from 1 review
Oral mucosa inflammation · adults
The review reported mixed findings for oral mucosa inflammation in reflux patients and did not formally demonstrate causation.
1 finding from 1 review
no estimate extracted
5 studies
GRADE not reported
Intervention not reported
Prevalence of GERD/reflux (esophagitis or positive pH testing) · Adults with dental erosion
Among patients with dental erosion, 64% to 75% had GERD or reflux findings across four studies; evidence is ungraded and not pooled.
1 finding from 1 review
Dental caries · adults
The review reported higher caries scores in reflux patients than healthy individuals but did not formally demonstrate causation.
1 finding from 1 review
no estimate extracted
3 studies
GRADE not reported
Caries susceptibility, enamel demineralisation, erosion, or microhardness · Permanent teeth or extracted human teeth with artificial lesions
The laboratory studies did not find increased susceptibility to caries or enamel demineralisation, but no firm conclusions can be drawn because of high risk of bias.
1 finding from 1 review
no estimate extracted
5 studies
GRADE not reported
Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)
No significant association between TT genotype vs CC + CT genotype of AMELX rs946252 and dental caries susceptibility (TT vs CC + CT model: OR 0.73, 95% CI 0.19-2.87) in the Control group: Caries-free subgroup; certainty not graded.
6 findings from 1 review
Show 3 more findings
Incidence of microleakage · Er,Cr:YSGG laser-prepared cavities restored with etch-and-rinse adhesive systems (in vitro)
Prior acid etching with etch-and-rinse adhesives did not significantly change microleakage after Er,Cr:YSGG preparation (RR 1.18, 95% CI 0.63-2.22; ungraded).
1 finding from 1 review
RR 1.18 [0.63, 2.22]
2 studies
GRADE not reported
Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)
No significant association between T allele vs C allele of AMELX rs6639060 and dental caries susceptibility (T vs C model: OR 1.08, 95% CI 0.63-1.85) in the Ethnicity: Caucasian subgroup; certainty not graded.
3 findings from 1 review
Salivary function impairment (buffering capacity, flow rate, oral pH) · Adults with gastroesophageal reflux disease (GERD) or laryngopharyngeal reflux (LPR)
Reflux is associated with impaired salivary function (notably reduced buffering capacity) as a proposed pathophysiological mechanism, based on several ungraded studies.
1 finding from 1 review
Mixed/controversial salivary findings: reduced salivary buffering capacity supported in three studies (Correa, Holbrook, Filipi) with low oral pH and reduced flow as additional factors in GERD patients, but Meurman and Schroeder found no significant salivary abnormalities; no pooled estimate.
6 studies
GRADE not reported
Intervention not reported
Anatomic form success rate
1 finding from 1 review
Intervention not reported
Absence of recurrent caries success rate
1 finding from 1 review
Intervention not reported
Marginal integrity success rate
1 finding from 1 review
Poor oral health-related quality of life (OHRQoL) · Children aged 3-12 years
Children aged 3 years had higher odds of poor OHRQoL than older children (OR 2.00, 95% CI 1.42-2.57; 2 studies; ungraded).
2 findings from 1 review
OR 2.00 [1.42, 2.57]
2 studies
GRADE not reported
OR 2.13 [1.50, 2.76]
2 studies
GRADE not reported
Dental caries susceptibility · Age group: Children (n=4) individuals with caries/high caries and controls
The pooled odds ratio was 0.99 (95% CI 0.81 to 1.23).
1 finding from 1 review
OR 0.99 [0.81, 1.23]
4 studies
GRADE not reported
Dental caries susceptibility · Ethnicity: Asian (n=2) individuals with caries/high caries and controls
The pooled odds ratio was 0.92 (95% CI 0.24 to 3.58).
1 finding from 1 review
OR 0.92 [0.24, 3.58]
2 studies
GRADE not reported
Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)
No significant association between TT genotype vs CC genotype of AMELX rs2106416 and dental caries susceptibility (TT vs CC model: OR 1.83, 95% CI 0.47-7.06); certainty not graded.
3 findings from 1 review
Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)
No significant association between TT genotype vs CC + CT genotype of ENAM rs3796703 and dental caries susceptibility (TT vs CC + CT model: OR 2.90, 95% CI 0.92-9.12); certainty not graded.
3 findings from 1 review
Oral/pharyngeal microbiota modifications · Adults with gastroesophageal reflux disease (GERD) or laryngopharyngeal reflux (LPR)
No eligible studies investigated reflux-related modifications of the oral or pharyngeal microbiota; this is an evidence gap identified by the review.
1 finding from 1 review
no estimate extracted
0 studies
No studies found
Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)
The pooled odds ratio was 0.90 (95% CI 0.23 to 3.63).
1 finding from 1 review