Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,447 questions · 2,590 findings · 266 reviews

No studies found 699 · 27%GRADE not reported 289 · 11.2%Very low 614 · 23.7%Low 605 · 23.4%Moderate 322 · 12.4%High 61 · 2.4%

Vedolizumab vs placebo

Improved IBDQ at week 52 · people with active UC

Vedolizumab probably leads to higher improved IBDQ at week 6 compared with placebo (moderate certainty).

2 findings from 1 review

TNF‐alpha antagonists vs placebo

IBDQ at weeks 6 or 8 · people with active UC

TNF‐alpha antagonists leads to higher improved IBDQ at weeks 6 or 8 compared with placebo (high certainty).

2 findings from 1 review

Testosterone vs other active intervention

Live birth · women undergoing assisted reproduction

It is very uncertain whether testosterone changes live birth ‐ Testosterone vs estradiol + OCP compared with other active interventions (very low certainty).

2 findings from 1 review