Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,703 questions · 3,824 findings · 858 reviews

No studies found 573 · 15%GRADE not reported 383 · 10%Very low 993 · 26%Low 1,062 · 27.8%Moderate 614 · 16.1%High 199 · 5.2%

Single dose primaquine at 0.4 to 0.5 mg/kg vs no primaquine, with artemisinin partner,

Participants infectious at day 8 · adults and children with malaria being treated with artemisinin combination treatment

Single dose primaquine at 0.4 to 0.5 mg/kg may leads to lower participants infectious at day 3‐4 compared with no primaquine, with artemisinin partner, (low certainty).

2 findings from 1 review

Single dose primaquine at 0.4 to 0.5 mg/kg vs no primaquine, with artemisinin partner,

Participants with gametocytes at day 3‐4, by PCR · adults and children with malaria being treated with artemisinin combination treatment

Single dose primaquine at 0.4 to 0.5 mg/kg showed no clear difference in participants with gametocytes at day 3‐4, by PCR compared with no primaquine, with artemisinin partner, (moderate certainty).

1 finding from 1 review

Single dose primaquine at 0.4 to 0.5 mg/kg vs no primaquine, with artemisinin partner,

Participants with gametocytes at day 8, by PCR · adults and children with malaria being treated with artemisinin combination treatment

Single dose primaquine at 0.4 to 0.5 mg/kg leads to lower participants with gametocytes at day 8, by PCR compared with no primaquine, with artemisinin partner, (high certainty).

1 finding from 1 review

Intramuscular vitamin K vs intravenous vitamin K

Presence of PIVKA II at day 25 ‐ 0.2 mg IV versus 0.5 mg IM · preterm infants

Intramuscular vitamin K showed no clear difference in presence of PIVKA II at day 25 ‐ 0.2 mg IV versus 0.5 mg IM compared with intravenous vitamin K (low certainty).

1 finding from 1 review

Motivational interviewing vs treatment

Over 50% less standard drinks per day Timeline follow back · concurrent problem alcohol and illicit drug users

Motivational interviewing (MI) showed no clear difference in greater than 50% reduction in number of standard drinks consumed per… compared with treatment (low certainty).

1 finding from 1 review

Motivational interviewing vs treatment

Abstinence from alcohol over the last 30 days · concurrent problem alcohol and illicit drug users

Motivational interviewing (MI) showed no clear difference in abstinence from alcohol over the last 30 days compared with treatment (low certainty).

1 finding from 1 review

Brief motivational interviewing (BMI) vs assessment‐only to reduce alcohol consumption

25% reduction of drinking days in the past 30 days · concurrent problem alcohol and illicit drug users

Brief motivational interviewing (BMI) showed no clear difference in 25% reduction of drinking days in the past 30 days compared with assessment‐only to reduce alcohol consumption (moderate certainty).

1 finding from 1 review

Brief motivational interviewing (BMI) vs assessment‐only to reduce alcohol consumption

50% reduction of drinking days in the past 30 days · concurrent problem alcohol and illicit drug users

Brief motivational interviewing (BMI) showed no clear difference in 50% reduction of drinking days in the past 30 days compared with assessment‐only to reduce alcohol consumption (moderate certainty).

1 finding from 1 review

Brief motivational interviewing (BMI) vs assessment‐only to reduce alcohol consumption

or more drinking days' reduction in the past 30 days · concurrent problem alcohol and illicit drug users

Brief motivational interviewing (BMI) probably leads to higher or more drinking days' reduction in the past 30 days compared with assessment‐only to reduce alcohol consumption (moderate certainty).

1 finding from 1 review

Percutaneous vascular interventions vs intravenous thrombolytic treatment

Symptomatic intracranial haemorrhage at

Percutaneous vascular interventions showed no clear difference in symptomatic intracranial haemorrhage within first 14 days compared with intravenous thrombolytic treatment (low certainty).

1 finding from 1 review