Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,703 questions · 3,824 findings · 858 reviews

No studies found 573 · 15%GRADE not reported 383 · 10%Very low 993 · 26%Low 1,062 · 27.8%Moderate 614 · 16.1%High 199 · 5.2%

Single dose primaquine at 0.4 to 0.5 mg/kg vs no primaquine, with non‐artemisinin partner,

Participants with gametocytes at day 8, by microscopy · adults and children with malaria being treated with non‐artemisinin treatment

Single dose primaquine at 0.4 to 0.5 mg/kg probably leads to lower participants with gametocytes at day 8, by microscopy compared with no primaquine, with non‐artemisinin partner, (moderate certainty).

1 finding from 1 review

Single dose primaquine at 0.75 mg/kg vs no primaquine, with non‐artemisinin partner,

Participants infectious at day 8 · adults and children with malaria being treated with non‐artemisinin treatment

It is very uncertain whether single dose primaquine at 0.75 mg/kg changes participants infectious at day 5 compared with no primaquine, with non‐artemisinin partner, (very low certainty).

2 findings from 1 review

Single dose primaquine at 0.75 mg/kg vs no primaquine, with non‐artemisinin partner,

Participants with gametocytes at day 5, by microscopy · adults and children with malaria being treated with non‐artemisinin treatment

Single dose primaquine at 0.75 mg/kg showed no clear difference in participants with gametocytes at day 5, by microscopy compared with no primaquine, with non‐artemisinin partner, (low certainty).

1 finding from 1 review

Single dose primaquine at 0.75 mg/kg vs no primaquine, with non‐artemisinin partner,

Participants with gametocytes at day 8, by microscopy · adults and children with malaria being treated with non‐artemisinin treatment

Single dose primaquine at 0.75 mg/kg probably leads to lower participants with gametocytes at day 8, by microscopy compared with no primaquine, with non‐artemisinin partner, (moderate certainty).

1 finding from 1 review

Single dose primaquine at 0.2 to 0.25 mg/kg vs no primaquine, with artemisinin partner,

Participants with gametocytes at day 8, by PCR · adults and children with malaria being treated with artemisinin combination treatment

Single dose primaquine at 0.2 to 0.25 mg/kg leads to lower participants with gametocytes at day 8 by PCR compared with no primaquine, with artemisinin partner, (high certainty).

1 finding from 1 review

Single dose primaquine at 0.4 to 0.5 mg/kg vs no primaquine, with artemisinin partner,

Participants with gametocytes at day 8, by PCR · adults and children with malaria being treated with artemisinin combination treatment

Single dose primaquine at 0.4 to 0.5 mg/kg leads to lower participants with gametocytes at day 8, by PCR compared with no primaquine, with artemisinin partner, (high certainty).

1 finding from 1 review

Intramuscular vitamin K vs intravenous vitamin K

Presence of PIVKA II at day 25 ‐ 0.2 mg IV versus 0.5 mg IM · preterm infants

Intramuscular vitamin K showed no clear difference in presence of PIVKA II at day 25 ‐ 0.2 mg IV versus 0.5 mg IM compared with intravenous vitamin K (low certainty).

1 finding from 1 review

Motivational interviewing vs treatment

Over 50% less standard drinks per day Timeline follow back · concurrent problem alcohol and illicit drug users

Motivational interviewing (MI) showed no clear difference in greater than 50% reduction in number of standard drinks consumed per… compared with treatment (low certainty).

1 finding from 1 review

Motivational interviewing vs treatment

Abstinence from alcohol over the last 30 days · concurrent problem alcohol and illicit drug users

Motivational interviewing (MI) showed no clear difference in abstinence from alcohol over the last 30 days compared with treatment (low certainty).

1 finding from 1 review

Brief motivational interviewing (BMI) vs assessment‐only to reduce alcohol consumption

25% reduction of drinking days in the past 30 days · concurrent problem alcohol and illicit drug users

Brief motivational interviewing (BMI) showed no clear difference in 25% reduction of drinking days in the past 30 days compared with assessment‐only to reduce alcohol consumption (moderate certainty).

1 finding from 1 review