Findings

What do systematic reviews say?

2,922 questions · 3,118 findings · 513 reviews

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No studies found 574 · 18.4%GRADE not reported 372 · 11.9%Very low 723 · 23.2%Low 854 · 27.4%Moderate 489 · 15.7%High 106 · 3.4%

Intervention not reported

Systolic BP ‐ Aliskiren 300 mg vs. placebo · primary hypertension

1 finding from 1 review

Blood pressure lowering efficacy of renin inhibitors for primary hypertension 2017 · Cochrane Headline outcomes only
no estimate extracted
10 studies · 3009 participants
Moderate

Intervention not reported

Systolic BP ‐ Aliskiren 600 mg vs. placebo · primary hypertension

1 finding from 1 review

Blood pressure lowering efficacy of renin inhibitors for primary hypertension 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 393 participants
Low

Intervention not reported

Diastolic BP ‐ Aliskiren 75 mg vs placebo · primary hypertension

1 finding from 1 review

Blood pressure lowering efficacy of renin inhibitors for primary hypertension 2017 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 1100 participants
Moderate

Intervention not reported

Diastolic BP ‐ Aliskiren 150 mg vs placebo · primary hypertension

1 finding from 1 review

Blood pressure lowering efficacy of renin inhibitors for primary hypertension 2017 · Cochrane Headline outcomes only
no estimate extracted
12 studies · 3783 participants
Moderate

Intervention not reported

Diastolic BP ‐ Aliskiren 300 mg vs placebo · primary hypertension

1 finding from 1 review

Blood pressure lowering efficacy of renin inhibitors for primary hypertension 2017 · Cochrane Headline outcomes only
no estimate extracted
10 studies · 3001 participants
Moderate

Intervention not reported

Diastolic BP ‐ Aliskiren 600 mg vs placebo · primary hypertension

1 finding from 1 review

Blood pressure lowering efficacy of renin inhibitors for primary hypertension 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 393 participants
Low

Intervention not reported

Diarrhoea ‐ Aliskiren 600 mg vs placebo · primary hypertension

The intervention may leads to higher diarrhoea ‐ Aliskiren 600 mg vs placebo (low certainty).

1 finding from 1 review

Blood pressure lowering efficacy of renin inhibitors for primary hypertension 2017 · Cochrane Headline outcomes only
RR 7 [2.48, 19.72]
2 studies · 592 participants
Low

Intervention not reported

Effect on systolic blood pressure (mean difference in systolic blood pressure) · adults with primary hypertension

The intervention showed no clear difference in effect on systolic blood pressure (mean difference in systolic blood… (moderate certainty).

1 finding from 1 review

Eplerenone for hypertension 2017 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 1437 participants
Moderate

Intervention not reported

Effect on diastolic blood pressure (mean difference in diastolic blood pressure) · adults with primary hypertension

The intervention showed no clear difference in effect on diastolic blood pressure (mean difference in diastolic… (moderate certainty).

1 finding from 1 review

Eplerenone for hypertension 2017 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 1437 participants
Moderate

Intervention not reported

Any adverse event · adults with primary hypertension

The intervention showed no clear difference in any adverse event (low certainty).

1 finding from 1 review

Eplerenone for hypertension 2017 · Cochrane Headline outcomes only
OR 1.07 [0.82, 1.41]
3 studies · 1105 participants
Low

Intervention not reported

Adverse event leading to withdrawal · adults with primary hypertension

The intervention showed no clear difference in adverse event leading to withdrawal (low certainty).

1 finding from 1 review

Eplerenone for hypertension 2017 · Cochrane Headline outcomes only
OR 1.1 [0.47, 2.55]
3 studies · 1105 participants
Low

Planned early birth vs expectant management

Maternal mortality or morbidity · pregnant women with hypertensive disorders from 34 weeks' gestation to term

Planned early delivery leads to lower composite maternal mortality and morbidity compared with expectant management (high certainty).

1 finding from 1 review

Planned early delivery versus expectant management for hypertensive disorders from 34 weeks gestation to term 2017 · Cochrane Headline outcomes only
RR 0.69 [0.57, 0.83]
2 studies · 1459 participants
High

Planned early birth vs expectant management

Composite infant mortality and morbidity · pregnant women with hypertensive disorders from 34 weeks' gestation to term

1 finding from 1 review

Planned early delivery versus expectant management for hypertensive disorders from 34 weeks gestation to term 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 1459 participants
GRADE not reported

Planned early birth vs expectant management

Caesarean section · pregnant women with hypertensive disorders from 34 weeks' gestation to term

Planned early delivery showed no clear difference in caesarean section compared with expectant management (moderate certainty).

1 finding from 1 review

Planned early delivery versus expectant management for hypertensive disorders from 34 weeks gestation to term 2017 · Cochrane Headline outcomes only
RR 0.91 [0.78, 1.07]
4 studies · 1728 participants
Moderate

Planned early birth vs expectant management

Maternal postpartum hospital stay (days) · pregnant women with hypertensive disorders from 34 weeks' gestation to term

1 finding from 1 review

Planned early delivery versus expectant management for hypertensive disorders from 34 weeks gestation to term 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 925 participants
Moderate

Planned early birth vs expectant management

Duration of hospital stay after delivery for baby (days) · pregnant women with hypertensive disorders from 34 weeks' gestation to term

1 finding from 1 review

Planned early delivery versus expectant management for hypertensive disorders from 34 weeks gestation to term 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 756 participants
Moderate

Glue vs suture

Chronic pain · patients with recurrence and pain in Lichtenstein inguinal hernioplasty

Glue may leads to lower chronic pain compared with suture (low certainty).

1 finding from 1 review

Mesh fixation with glue versus suture for chronic pain and recurrence in Lichtenstein inguinal hernioplasty 2017 · Cochrane Headline outcomes only
OR 0.63 [0.44, 0.91]
10 studies · 1473 participants
Low

Glue vs suture

Hernia recurrence · patients with recurrence and pain in Lichtenstein inguinal hernioplasty

Glue showed no clear difference in hernia recurrence compared with suture (low certainty).

1 finding from 1 review

Mesh fixation with glue versus suture for chronic pain and recurrence in Lichtenstein inguinal hernioplasty 2017 · Cochrane Headline outcomes only
OR 1.44 [0.63, 3.28]
12 studies · 1987 participants
Low

Glue vs suture

Duration of operation (mins) · patients with recurrence and pain in Lichtenstein inguinal hernioplasty

1 finding from 1 review

Mesh fixation with glue versus suture for chronic pain and recurrence in Lichtenstein inguinal hernioplasty 2017 · Cochrane Headline outcomes only
no estimate extracted
9 studies · 1790 participants
Low

Glue vs suture

Wound/superficial infection · patients with recurrence and pain in Lichtenstein inguinal hernioplasty

Glue showed no clear difference in wound/superficial infection compared with suture (low certainty).

1 finding from 1 review

Mesh fixation with glue versus suture for chronic pain and recurrence in Lichtenstein inguinal hernioplasty 2017 · Cochrane Headline outcomes only
OR 1.23 [0.37, 4.11]
7 studies · 818 participants
Low