What do systematic reviews say?

Honey vs salbutamol

• Honey for acute cough in children 2018 · Cochrane Headline outcomes only
  no estimate extracted
  3 participants
  GRADE not reported

Honey vs salbutamol

• Honey for acute cough in children 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 100 participants
  Moderate

Intervention not reported

• Parenteral opioids for maternal pain management in labour 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Low

Intervention not reported

• Parenteral opioids for maternal pain management in labour 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Very low

Intervention not reported

• Parenteral opioids for maternal pain management in labour 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Very low

Pharmacological detoxification treatment vs other pharmacological detoxification treatment

• Pharmacological therapies for management of opium withdrawal 2018 · Cochrane Headline outcomes only
  no estimate extracted
  72 participants
  Very low
• Pharmacological therapies for management of opium withdrawal 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 40 participants
  Low
• Pharmacological therapies for management of opium withdrawal 2018 · Cochrane Headline outcomes only
  no estimate extracted
  60 participants
  Very low

Hypocaloric nutrition vs control

• Prescribed hypocaloric nutrition support for critically‐ill adults 2018 · Cochrane Headline outcomes only
  no estimate extracted
  7 studies · 2611 participants
  Very low

Hypocaloric nutrition vs control

• Prescribed hypocaloric nutrition support for critically‐ill adults 2018 · Cochrane Headline outcomes only
  no estimate extracted
  10 studies · 1677 participants
  Very low

Hypocaloric nutrition vs control

• Prescribed hypocaloric nutrition support for critically‐ill adults 2018 · Cochrane Headline outcomes only
  no estimate extracted
  11 studies · 2942 participants
  Very low

Hypocaloric nutrition vs control

• Prescribed hypocaloric nutrition support for critically‐ill adults 2018 · Cochrane Headline outcomes only
  no estimate extracted
  12 studies · 3000 participants
  Very low

Cervical dilatation vs no dilatation

Cervical dilatation showed no clear difference in febrile morbidity (at least 38° Celsius, measured on 2/10 days… compared with no dilatation (low certainty).

• Mechanical dilatation of the cervix during elective caesarean section before the onset of labour for reducing… 2018 · Cochrane Headline outcomes only
  RR 1.18 [0.76, 1.85]
  7 studies · 2126 participants
  Low

Single dose primaquine at 0.2 to 0.25 mg/kg vs no primaquine, with artemisinin partner,

Single dose primaquine at 0.2 to 0.25 mg/kg may leads to lower participants infectious at day 3‐4 compared with no primaquine, with artemisinin partner, (low certainty).

• Primaquine or other 8‐aminoquinolines for reducing Plasmodium falciparum transmission 2018 · Cochrane Headline outcomes only
  RR 0.12 [0.02, 0.88]
  3 studies · 105 participants
  Low
• Primaquine or other 8‐aminoquinolines for reducing Plasmodium falciparum transmission 2018 · Cochrane Headline outcomes only
  RR 0.34 [0.07, 1.58]
  4 studies · 243 participants
  Low

Single dose primaquine at 0.75 mg/kg vs no primaquine, with artemisinin partner,

Single dose primaquine at 0.75 mg/kg showed no clear difference in participants infectious at day 3‐4 compared with no primaquine, with artemisinin partner, (low certainty).

• Primaquine or other 8‐aminoquinolines for reducing Plasmodium falciparum transmission 2018 · Cochrane Headline outcomes only
  RR 0.2 [0.02, 1.68]
  1 study · 101 participants
  Low
• Primaquine or other 8‐aminoquinolines for reducing Plasmodium falciparum transmission 2018 · Cochrane Headline outcomes only
  RR 0.18 [0.02, 1.41]
  2 studies · 181 participants
  Low

Single dose primaquine at 0.75 mg/kg vs no primaquine, with artemisinin partner,

Single dose primaquine at 0.75 mg/kg showed no clear difference in participants with gametocytes at day 3‐4, by PCR compared with no primaquine, with artemisinin partner, (low certainty).

• Primaquine or other 8‐aminoquinolines for reducing Plasmodium falciparum transmission 2018 · Cochrane Headline outcomes only
  RR 0.92 [0.75, 1.13]
  2 studies · 290 participants
  Low

Single dose primaquine at 0.75 mg/kg vs no primaquine, with artemisinin partner,

Single dose primaquine at 0.75 mg/kg leads to lower participants with gametocytes at day 8, by PCR compared with no primaquine, with artemisinin partner, (high certainty).

• Primaquine or other 8‐aminoquinolines for reducing Plasmodium falciparum transmission 2018 · Cochrane Headline outcomes only
  RR 0.31 [0.23, 0.43]
  5 studies · 793 participants
  High

Single dose primaquine at 0.4 to 0.5 mg/kg vs no primaquine, with non‐artemisinin partner,

Single dose primaquine at 0.4 to 0.5 mg/kg showed no clear difference in participants with gametocytes at day 4‐5, by microscopy compared with no primaquine, with non‐artemisinin partner, (moderate certainty).

• Primaquine or other 8‐aminoquinolines for reducing Plasmodium falciparum transmission 2018 · Cochrane Headline outcomes only
  RR 0.83 [0.62, 1.13]
  2 studies · 221 participants
  Moderate

Single dose primaquine at 0.4 to 0.5 mg/kg vs no primaquine, with non‐artemisinin partner,

Single dose primaquine at 0.4 to 0.5 mg/kg probably leads to lower participants with gametocytes at day 8, by microscopy compared with no primaquine, with non‐artemisinin partner, (moderate certainty).

• Primaquine or other 8‐aminoquinolines for reducing Plasmodium falciparum transmission 2018 · Cochrane Headline outcomes only
  RR 0.6 [0.49, 0.75]
  2 studies · 216 participants
  Moderate

Single dose primaquine at 0.75 mg/kg vs no primaquine, with non‐artemisinin partner,

Single dose primaquine at 0.75 mg/kg probably leads to lower participants with gametocytes at day 8, by microscopy compared with no primaquine, with non‐artemisinin partner, (moderate certainty).

• Primaquine or other 8‐aminoquinolines for reducing Plasmodium falciparum transmission 2018 · Cochrane Headline outcomes only
  RR 0.39 [0.25, 0.62]
  4 studies · 186 participants
  Moderate

Single dose primaquine at 0.2 to 0.25 mg/kg vs no primaquine, with artemisinin partner,

Single dose primaquine at 0.2 to 0.25 mg/kg showed no clear difference in participants with gametocytes at day 3 to 4 by PCR compared with no primaquine, with artemisinin partner, (moderate certainty).

• Primaquine or other 8‐aminoquinolines for reducing Plasmodium falciparum transmission 2018 · Cochrane Headline outcomes only
  RR 1.02 [0.87, 1.21]
  3 studies · 414 participants
  Moderate

Single dose primaquine at 0.2 to 0.25 mg/kg vs no primaquine, with artemisinin partner,

Single dose primaquine at 0.2 to 0.25 mg/kg leads to lower participants with gametocytes at day 8 by PCR compared with no primaquine, with artemisinin partner, (high certainty).

• Primaquine or other 8‐aminoquinolines for reducing Plasmodium falciparum transmission 2018 · Cochrane Headline outcomes only
  RR 0.52 [0.41, 0.65]
  4 studies · 532 participants
  High