Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

461 questions · 473 findings · 36 reviews · HIV/AIDS

No studies found 38 · 8%GRADE not reported 9 · 1.9%Very low 126 · 26.6%Low 127 · 26.8%Moderate 152 · 32.1%High 21 · 4.4%

Intervention not reported

Discontinuation for adverse events · HIV‐infected adult patients treated with a PI‐containing regimen with undetectable viral load

The intervention showed no clear difference in discontinuation for adverse events (moderate certainty).

1 finding from 1 review

Intervention not reported

Death and AIDS related events · HIV‐infected adult patients treated with a PI‐containing regimen with undetectable viral load

The intervention showed no clear difference in death and AIDS related events (low certainty).

1 finding from 1 review

Intervention not reported

HIV incidence (observational studies‐‐sensitivity analysis) · Serodiscordant couples

The intervention probably leads to lower HIV incidence (observational studies‐‐sensitivity analysis) (moderate certainty).

1 finding from 1 review

Intervention not reported

HIV incidence: CD4 subgroups (<200 cells/µL) (observational studies) · Serodiscordant couples

The intervention may leads to lower HIV incidence: CD4 subgroups (<200 cells/µL) (observational studies) (low certainty).

1 finding from 1 review

Intervention not reported

HIV incidence: CD4 subgroups (200‐350 CD4 cells/µL) (observational studies) · Serodiscordant couples

It is very uncertain whether the intervention changes HIV incidence: CD4 subgroups (200‐350 CD4 cells/µL) (observational… (very low certainty).

1 finding from 1 review

Intervention not reported

HIV incidence: CD4 subgroups (350 or more CD4 cells/µL) (observational studies) · Serodiscordant couples

The intervention may leads to lower HIV incidence: CD4 subgroups (350 or more CD4 cells/µL)… (low certainty).

1 finding from 1 review

Intervention not reported

Virologically linked HIV incidence: CD4 subgroups (350 or more CD4 cells/µL) (RCT) · Serodiscordant couples

The intervention leads to lower virologically linked HIV incidence: CD4 subgroups (350 or more CD4… (high certainty).

1 finding from 1 review