Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

309 questions · 325 findings · 45 reviews · Acute Respiratory Infections

No studies found 38 · 11.7%GRADE not reported 31 · 9.5%Very low 54 · 16.6%Low 78 · 24%Moderate 106 · 32.6%High 18 · 5.5%

Palivizumab vs Placebo, no intervention or usual care (with or without placebo)

Hospitalisation due to respiratory‐related illness · children (0 to 24 months)

Palivizumab probably leads to lower hospitalisation due to respiratory‐related illness compared with placebo, no intervention or standard care (moderate certainty).

1 finding from 1 review

Probiotics vs placebo

Proportion of children with AOM (overall) · children up to age 18 years

Probiotic probably leads to lower proportion of children with AOM (overall) compared with placebo (moderate certainty).

1 finding from 1 review

Probiotics vs placebo

Proportion of children with AOM: children not prone to AOM · children up to age 18 years

Probiotic probably leads to lower proportion of children with AOM: children not prone to AOM compared with placebo (moderate certainty).

1 finding from 1 review

Probiotics vs placebo

Proportion of children with AOM: children prone to AOM · children up to age 18 years

Probiotic showed no clear difference in proportion of children with AOM: children prone to AOM compared with placebo (high certainty).

1 finding from 1 review

Probiotics vs placebo

Difference in proportion of children with other infections · children up to age 18 years

Probiotic probably leads to lower difference in proportion of children with other infections compared with placebo (moderate certainty).

1 finding from 1 review