Cochrane · systematic review · CD001269
Vaccines for preventing influenza in healthy adults
Demicheli, V, Jefferson, T, Ferroni, E, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
Acute Respiratory InfectionsAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 3 · 50%Moderate 2 · 33.3%High 1 · 16.7%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Inactivated parenteral influenza vaccine compared to placebo or 'do nothing' for preventing influenza in healthy adults
Population: healthy adults
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Influenza assessed by laboratory confirmation Timing of assessment: most studies tested vaccines over a single influenza season Inactivated parenteral influenza vaccine vs placebo or 'do nothing' | RR 0.41 [0.36, 0.47] | 25 studies · 71221 participants | Moderate Downgraded: risk of bias, imprecision, indirectness |
Influenza‐like illness assessed by subjective report Timing of assessment: most studies tested vaccines over a single influenza season Inactivated parenteral influenza vaccine vs placebo or 'do nothing' | RR 0.84 [0.75, 0.95] | 16 studies · 25795 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Hospitalisations Timing of assessment: single influenza season Inactivated parenteral influenza vaccine vs placebo or 'do nothing' | RR 0.96 [0.85, 1.08] | 3 studies · 11924 participants | Low Downgraded: risk of bias, imprecision |
Time off work Timing of assessment: single influenza season Inactivated parenteral influenza vaccine vs placebo or 'do nothing' | no estimate extracted | 4 studies · 3726 participants | Low Downgraded: risk of bias, inconsistency |
Fever assessed by subjective report Timing of assessment: single influenza season Inactivated parenteral influenza vaccine vs placebo or 'do nothing' | RR 1.55 [1.26, 1.91] | 13 studies · 23850 participants | High |
Nausea or vomiting assessed by subjective report Timing of assessment: single influenza season Inactivated parenteral influenza vaccine vs placebo or 'do nothing' | RR 1.8 [0.65, 5.04] | 4 studies · 6315 participants | Low Downgraded: risk of bias, imprecision |