Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

279 questions · 289 findings · 28 reviews · Headline outcomes only

No studies found 81 · 28%GRADE not reported 9 · 3.1%Very low 90 · 31.1%Low 67 · 23.2%Moderate 24 · 8.3%High 18 · 6.2%

NSAID (single administration, any dose) vs paracetamol

Need for additional analgesia (4 hours after administration) · women with perineal pain in the early postpartum period

It is very uncertain whether NSAID (single administration, any dose) changes need for additional analgesia (4 hours after administration) compared with paracetamol (very low certainty).

1 finding from 1 review

NSAID (single administration, any dose) vs paracetamol

Need for additional analgesia (6 hours after administration) · women with perineal pain in the early postpartum period

NSAID (single administration, any dose) may leads to lower need for additional analgesia (6 hours after administration) compared with paracetamol (low certainty).

1 finding from 1 review

NSAID (single administration, any dose) vs paracetamol

Maternal drug adverse effects (6 hours after administration) · women with perineal pain in the early postpartum period

It is very uncertain whether NSAID (single administration, any dose) changes maternal drug adverse effects (6 hours after administration) compared with paracetamol (very low certainty).

1 finding from 1 review

NSAID (single administration, any dose) vs paracetamol

Relief of pain · women with perineal pain in the early postpartum period

NSAID (single administration, any dose) may leads to higher adequate pain relief (4 hours after administration) compared with paracetamol (low certainty).

2 findings from 1 review

NSAIDs vs combination (paracetamol and opioid) analgesic

Little or no pain at 1 to 3 days · people with acute soft tissue injury, such as ankle sprain

It is very uncertain whether NSAID changes little or no pain at 1 to 3 days compared with combination (paracetamol and opioid) analgesic (very low certainty).

2 findings from 1 review

NSAIDs vs combination (paracetamol and opioid) analgesic

Return to function on day 7 or later Assessed as 'cure' · people with acute soft tissue injury, such as ankle sprain

It is very uncertain whether NSAID changes return to function on day 7 or later Assessed as 'cure' compared with combination (paracetamol and opioid) analgesic (very low certainty).

1 finding from 1 review

NSAIDs vs combination (paracetamol and opioid) analgesic

Gastrointestinal adverse events · people with acute soft tissue injury, such as ankle sprain

It is very uncertain whether NSAID changes gastrointestinal adverse events compared with combination (paracetamol and opioid) analgesic (very low certainty).

1 finding from 1 review

NSAIDs vs combination (paracetamol and opioid) analgesic

Neurological adverse effects · people with acute soft tissue injury, such as ankle sprain

It is very uncertain whether NSAID changes neurological adverse events compared with combination (paracetamol and opioid) analgesic (very low certainty).

1 finding from 1 review