Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

215 questions · 236 findings · 28 reviews · Headline outcomes only

No studies found 45 · 19.1%GRADE not reported 15 · 6.4%Very low 78 · 33.1%Low 50 · 21.2%Moderate 34 · 14.4%High 14 · 5.9%

Protease‐modulating matrix dressing regimen vs any other dressing regimen

Proportion of participants with healed ulcers at 6 weeks · people with venous leg ulcers

It is very uncertain whether protease‐modulating matrix dressing regimen changes proportion of participants healed ‐ short term (4‐8 weeks) compared with any other dressing regimen (very low certainty).

1 finding from 1 review

Protease‐modulating matrix dressing regimen vs any other dressing regimen

Proportion of participants with healed ulcers at 12 weeks · people with venous leg ulcers

Protease‐modulating matrix dressing regimen showed no clear difference in proportion of participants healed ‐ medium term (12 weeks) compared with any other dressing regimen (low certainty).

1 finding from 1 review

Protease‐modulating matrix dressing regimen vs any other dressing regimen

Proportion of participants healed ‐ long term (over 24 weeks) · people with venous leg ulcers

Protease‐modulating matrix dressing regimen showed no clear difference in proportion of participants healed ‐ long term (over 24 weeks) compared with any other dressing regimen (low certainty).

1 finding from 1 review

Protease‐modulating matrix dressing regimen vs any other dressing regimen

Proportion of participants with 1 or more adverse events at 2‐12 weeks · people with venous leg ulcers

Protease‐modulating matrix dressing regimen showed no clear difference in proportion of participants with 1 or more adverse events at 2‐12 weeks compared with any other dressing regimen (low certainty).

1 finding from 1 review

Cervical cerclage in combination with antibiotics and tocolytics vs cervical cerclage

Serious neonatal morbidity

It is very uncertain whether cervical cerclage in combination with antibiotics and tocolytics changes serious neonatal morbidity (Reported in Miller 2014 as 'composite… compared with cervical cerclage alone (very low certainty).

1 finding from 1 review