Disease-free survival · Adults with oral cavity or oropharyngeal cancer with nodal disease (stage N2 or N3)
1 finding from 1 review
Patient-reported altered sensation (spontaneous or evoked: anaesthesia/paraesthesia/dysaesthesia/hyperalgesia/allodynia) · Patients of any age in any setting requiring intervention for iatrogenic injury to the inferior alveolar or lingual nerve
It is very uncertain whether low-level laser therapy (photon-plus GaAlAs diode laser; 70 mW… changes patient-reported altered sensation (spontaneous or evoked:… compared with placebo (sham) laser therapy (very low certainty).
2 findings from 1 review
Somatosensory evoked potentials · Patients of any age in any setting requiring intervention for iatrogenic injury to the inferior alveolar or lingual nerve
The review found no eligible studies for this question.
1 finding from 1 review
Difficulty speaking · Patients of any age in any setting requiring intervention for iatrogenic injury to the inferior alveolar or lingual nerve
The review found no eligible studies for this question.
1 finding from 1 review
Difficulty eating · Patients of any age in any setting requiring intervention for iatrogenic injury to the inferior alveolar or lingual nerve
The review found no eligible studies for this question.
1 finding from 1 review
Mechanosensory perception (load in grams to elicit sensation; Semmes Weinstein monofilaments) · Patients of any age in any setting requiring intervention for iatrogenic injury to the inferior alveolar or lingual nerve
Low-level laser therapy (photon-plus GaAlAs diode laser; 70 mW… led to higher mechanosensory perception (load in grams to elicit sensation; Semmes… compared with placebo (sham) laser therapy; GRADE not reported.
1 finding from 1 review
Quality of life · Patients of any age in any setting requiring intervention for iatrogenic injury to the inferior alveolar or lingual nerve
The review found no eligible studies for this question.
1 finding from 1 review
Adverse events · Patients of any age in any setting requiring intervention for iatrogenic injury to the inferior alveolar or lingual nerve
The review found no eligible studies for this question.
1 finding from 1 review
Pain · Patients of any age in any setting requiring intervention for iatrogenic injury to the inferior alveolar or lingual nerve
The review found no eligible studies for this question.
1 finding from 1 review
Taste · Patients of any age in any setting requiring intervention for iatrogenic injury to the inferior alveolar or lingual nerve
The review found no eligible studies for this question.
1 finding from 1 review
Thermosensory (thermal) perception · Patients of any age in any setting requiring intervention for iatrogenic injury to the inferior alveolar or lingual nerve
Low-level laser therapy (photon-plus GaAlAs diode laser; 70 mW… showed no clear difference in thermosensory (thermal) perception compared with placebo (sham) laser therapy; GRADE not reported.
1 finding from 1 review
Patient satisfaction · Patients of any age in any setting requiring intervention for iatrogenic injury to the inferior alveolar or lingual nerve
The review found no eligible studies for this question.
1 finding from 1 review
Oral candidiasis prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
cART was associated with a significantly lower prevalence of oral candidiasis in CLWH (very low certainty).
1 finding from 1 review
OR 0.35 [0.24, 0.51]
Studies not reported
Very low
Any intervention for KCOT (e.g. enucleation), alone or combined with an adjunctive therapy (ostectomy, cryotherapy, or Carnoy's solution) vs A different intervention (e.g. enucleation versus marsupialisation), or the same surgical intervention without the adjunctive therapy
Outcome not reported · Adults over the age of 18 with a validated diagnosis of solitary keratocystic odontogenic tumours (KCOT) arising in the jaw bones of the…
The review found no eligible studies for this question.
1 finding from 1 review
Total mortality · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials…
Pre-operative radiotherapy (plus surgery) showed no clear difference in total mortality compared with surgery alone; GRADE not reported.
1 finding from 1 review
HR 0.83 [0.64, 1.07]
1 study
GRADE not reported
Locoregional control · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials…
Pre-operative radiotherapy (plus surgery) showed no clear difference in locoregional control compared with surgery alone; GRADE not reported.
1 finding from 1 review
RR 0.63 [0.28, 1.46]
1 study
GRADE not reported
Oral candidiasis prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
Oral candidiasis prevalence did not differ significantly between treatment-naive CLWH and those on monotherapy or dual therapy (very low certainty).
1 finding from 1 review
Salivary immunoglobulin A (SIgA) concentration · Children and adolescents (<18 years) living with HIV (CLWH)
Evidence on salivary IgA in CLWH on versus off ART was divergent and inconclusive (very low certainty).
1 finding from 1 review
Linear gingival erythema prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
No significant difference in linear gingival erythema between CLWH with and without ART (very low certainty).
1 finding from 1 review
OR 1.29 [0.58, 2.88]
Studies not reported
Very low
Acute necrotising ulcerative gingivitis prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
Acute necrotising ulcerative gingivitis was significantly more prevalent in treatment-naive CLWH than in those on ART (very low certainty).
1 finding from 1 review
OR 0.00 [0.00, 0.02]
Studies not reported
Very low